Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds

Silva, Ana Paula dos Santos C.L. da; Oliveira, George Laylson da Silva; Medeiros, Shirlene Cesário; Sousa, Allyson Martins Lopes; Lopes, Lawrence Gonzaga; David, Jorge M.; Costa, Joaquim Soares da; Freitas, Rivelilson Mendes de

doi:10.1016/j.phymed.2016.02.013

Cited by 21 publications

(20 citation statements)

References 6 publications

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“…Moreover, similar to our results for GFC, hyperforin (0.1-0.38 mg/kg, i.p) did not change locomotion parameters in rats, compared to the control group in an experiment conducted by Cervo et al [22]. Recently, a study reported that acute treatment with GFC produced no change in locomotor activity in mice [10]. Our experiments revealed that GFC did not influence the results of the open-field model after 28 days of treatment, indicating that this compound was not able to alter locomotor and exploratory activity of the animals even after subchronic treatment.…”

Section: Resultssupporting

confidence: 90%

“…. Recently, a study reported that acute treatment with GFC produced no change in locomotor activity in mice . Our experiments revealed that GFC did not influence the results of the open‐field model after 28 days of treatment, indicating that this compound was not able to alter locomotor and exploratory activity of the animals even after subchronic treatment.…”

Section: Resultsmentioning

confidence: 46%

“…Da Silva et al . showed that acute treatment with GFC 25, 50 and 75 mg/kg did not affect motor co‐ordination. Also, Mohanasundari et al .…”

Section: Resultsmentioning

confidence: 92%

“…There was no significant difference between the groups (p = 0.232), suggesting that the doses of GFC tested did not induce neurological effects on motor co-ordination or muscle relaxation. Da Silva et al [10] showed that acute treatment with GFC 25, 50 and 75 mg/kg did not affect motor co-ordination. Also, Mohanasundari et al [20] demonstrated that the performance of mice treated with the ethanolic extract of H. perforatum, a species rich in hyperforin that is structurally similar to GFC, was not impaired in the rotarod test.…”

Section: Resultsmentioning

confidence: 98%

“…The toxicological profile of GFC is not clear. In a previous study, the oral administration of repeated doses of GFC (25, 50 and 75 mg/kg) showed no haematological and biochemical toxicity , and no toxicological effects were observed in oral and intraperitoneal acute tests using the maximum dose of 2000 mg/kg . However, the anticonvulsant study showing the most promising pharmacological properties of GFC was performed using the intraperitoneal route .…”

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confidence: 97%

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A 28‐day Sub‐acute Genotoxic and Behavioural Assessment of Garcinielliptone FC

Coelho

Prado

Rossato

et al. 2018

Basic Clin Pharma Tox

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Garcinielliptone FC (GFC) is a polyisoprenylated benzophenone isolated from Platonia insignis Mart (Clusiaceae) with promising anticonvulsant properties. However, its safe use and other effects on the central nervous system require assessment. This study assessed the toxicological effects of GFC using the comet assay and the micronucleus test in mice treated for 28 days. A behavioural model was employed to detect possible injuries on the central nervous system. Mice treated with GFC (2, 10 and 20 mg/kg; i.p.) daily for 28 days were submitted to rotarod test, open-field test and tail suspension test (TST). After the behaviour tasks, biological samples were assessed to evaluate genotoxic and mutagenic effects using the comet assay and the micronucleus test. Garcinielliptone FC did not impair the performance of the animals in the rotarod and open-field tests, with no antidepressant-like effect in TST. No genotoxic effects in blood and cerebral cortex were observable in the comet assay; however, there was a significant increase in index and frequency of damage in liver after treatment with GFC 20 mg/kg. Garcinielliptone FC did not increase micronucleus frequency in bone marrow. At the tested doses, GFC was not toxic to the CNS and did not induce genotoxic damage to blood or bone narrow cells. DNA damage to liver tissue was caused only by the highest dose, although no mutagenic potential was observed.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 46%

“…Da Silva et al . showed that acute treatment with GFC 25, 50 and 75 mg/kg did not affect motor co‐ordination. Also, Mohanasundari et al .…”

Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 98%

mentioning

confidence: 97%

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A 28‐day Sub‐acute Genotoxic and Behavioural Assessment of Garcinielliptone FC

Coelho

Prado

Rossato

et al. 2018

Basic Clin Pharma Tox

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Natural Toxins in Brazilian Unconventional Food Plants: Uses and Safety

Pereira

Medeiros

Araújo

2021

Local Food Plants of Brazil

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Brazil presents one of the greatest biodiversities in the world. Whether native, cultivated, or naturalized, over 48,572 species are currently recognized in the Brazilian flora. Data provided by the Brazilian Ministry of the Environment reveals more than 200 thousand registered species in the Amazon, Caatinga, Cerrado, Atlantic Forest, Pantanal, and Pampa biomes. This approaches 15% of all plant species on the planet (do Brasil 2020; Flora do Brasil 2020 em construção 2020).Many of these native Brazilian species can be used as food sources, but their potential is still little known, either due to the lack of common knowledge, to restricted distribution/or use in the country, or to simple negligence. Such plants are currently known as unconventional food plants (UFP). UFP refers to plants that have one or more parts with food potential yet with unusual use; those which are not quickly recognized or acquired by the population of a given community; and plants that generally have no market value, being only sold in small scale, or are discarded, or plants which only possess one quality that is important to the market. These UFP can be described as native or exotic, cultivated or spontaneous, and can be adapted to local environments (Kinupp and de Barros 2007). Taken together, UFP become

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