Pre-concentration of capsaicinoids from different cultivars of Capsicum annuum after extraction in heterogenous mixtures

Genovese, Salvatore; Epifano, Francesco; Marchetti, Lorenzo; Bastianini, Maria; Cardellini, Fabio; Spogli, Roberto; Fiorito, Serena

doi:10.1016/j.jfca.2021.104052

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…Solid-phase absorbents like magnesium aluminum azelate and bentonite can uptake up to 91% of the capsaicinoids from C. annuum cv. Big Black Mama Mustard extracts . Capsaicinoids as markers of gutter oil were absorbed on a magnetic solid phase using a reusable graphene oxide–Fe 3 O 4 nanocomposite and were quantified using UHPLC-MS/MS up to a lower limit of 0.4 μg L –1 …”

Section: Detection and Separation Methods For Capsicum Secondary Meta...mentioning

confidence: 99%

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Genetic Regulation, Environmental Cues, and Extraction Methods for Higher Yield of Secondary Metabolites in Capsicum

Islam

Rawoof

Kumar

et al. 2023

J. Agric. Food Chem.

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Capsicum (chili pepper) is a widely popular and highly consumed fruit crop with beneficial secondary metabolites such as capsaicinoids, carotenoids, flavonoids, and polyphenols, among others. Interestingly, the secondary metabolite profile is a dynamic function of biosynthetic enzymes, regulatory transcription factors, developmental stage, abiotic and biotic environment, and extraction methods. We propose active manipulable genetic, environmental, and extraction controls for the modulation of quality and quantity of desired secondary metabolites in Capsicum species. Specific biosynthetic genes such as Pun (AT3) and AMT in the capsaicinoids pathway and PSY, LCY, and CCS in the carotenoid pathway can be genetically engineered for enhanced production of capsaicinoids and carotenoids, respectively. Generally, secondary metabolites increase with the ripening of the fruit; however, transcriptional regulators such as MYB, bHLH, and ERF control the extent of accumulation in specific tissues. The precise tuning of biotic and abiotic factors such as light, temperature, and chemical elicitors can maximize the accumulation and retention of secondary metabolites in pre-and postharvest settings. Finally, optimized extraction methods such as ultrasonication and supercritical fluid method can lead to a higher yield of secondary metabolites. Together, the integrated understanding of the genetic regulation of biosynthesis, elicitation treatments, and optimization of extraction methods can maximize the industrial production of secondary metabolites in Capsicum.

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Section: Detection and Separation Methods For Capsicum Secondary Meta...mentioning

confidence: 99%

“…Big Black Mama Mustard extracts. 265 Capsaicinoids as markers of gutter oil were absorbed on a magnetic solid phase using a reusable graphene oxide−Fe 3 O 4 nanocomposite and were quantified using UHPLC-MS/MS up to a lower limit of 0.4 μg L −1 . 266 9.3.…”

Section: Detection and Separation Methods Formentioning

confidence: 99%

Genetic Regulation, Environmental Cues, and Extraction Methods for Higher Yield of Secondary Metabolites in Capsicum

Islam

Rawoof

Kumar

et al. 2023

J. Agric. Food Chem.

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“…37 LDHs are ideally biocompatible and have several industrial applications to produce a plethora of cosmetic, nutraceutical, and pharmaceutical preparations. 38 During the last three years, lamellar solids have found extensive use in phytochemistry and have been shown to be tremendously efficient for the selective extraction of classes of plant secondary metabolites like flavonoids, catechins, alkaloids, 39 diarylheptanoids, 40 bitter secoiridoids, 41,42 capsaicinoids, 43 oxyprenylated coumarins, 44 tetraterpenes, 45 and anthocyans. 46 48 The pattern of adsorption was practically the same, allowing good to excellent recovery of anthraquinones (all or some) by using the same two sorbents mentioned above in addition to magnesium aluminum azelate, which also displayed good performance.…”

Section: Lamellar Solidsmentioning

confidence: 99%

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Palumbo

Fiorito

Epifano

et al. 2023

Phytochemical Analysis

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Introduction: Solid-phase extraction applied to plant matrices is nowadays a wellvalidated technique allowing to concentrate and purify different secondary metabolites. Several classes of phytochemicals have been selectively extracted by this methodology. During the last decade attention has been focused on biologically active anthraquinones from numerous sources like edible, healthy, and medicinal plants. Objectives: The aim of this review is to provide a detailed literature survey of the solid-phase adsorption methodologies for the extraction of natural anthraquinones reported so far and to discuss and propose future directions in this field of research. Materials and Methods: Substructure search was performed in the SciFinder Scholar, PubMed, Medline, and Scopus databases. Results: The first report about application of solid-phase adsorption for the purification of anthraquinones appeared in the literature in 2002. From this date, and in particular during recent years, the most notable examples included the use of chitin-and chitosan-based polymers, of molecularly imprinted polymers, of coated magnetic nanoparticles, of miniaturized matrix solid-phase dispersion, of functionalized resins, of differently structured lamellar solids, and finally of vortex-synchronized matrix solid-phase dispersion. Conclusions:The herein detailed solid-phase adsorption methodologies are powerful tools to selectively extract natural anthraquinones and/or provide anthraquinoneenriched phytopreparations. Nevertheless, many other important methods have been applied to synthetic anthraquinones (e.g., azo dyes). These could be conveniently employed also for natural anthranoids. Studies in this field are discussed in this review article.

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“…9 This seems to greatly facilitate the adsorption and consequently the interaction with organic compounds, like gentiopicroside (1) and amarogentin (2), presumably due to interactions of a lipophilic nature or of the van der Waals type. The present results confirm a trend exhibited by these same materials (especially by Mg Al azelate, entry E) with other classes of natural products like anthraquinones, 10 phenolic acids, flavonoids, purine alkaloids, 11 diarylheptanoids, 12 capsaicinoids, 13 oxyprenylated coumarins, 14 apocarotenoids, 15 and anthocyanins. 16 Further changes of experimental parameters and conditions (e.g., a modified operational time and an increase of temperature) led to worse data (e.g., lower extractive yields and chemical degradation) than those described above.…”

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confidence: 99%

Leaves of Yellow Gentian (Gentiana lutea) as an Alternative Source of Bitter Secoiridoid Glycosides

et al. 2022

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In a search for methods of manufacturing bitter principles from Gentiana lutea, mainly represented by gentiopicroside (1) and amarogentin (2), as an alternative to extraction from the roots of this plant, in this short communication it is shown that the leaves of this plant can be regarded as an additional source of such phytochemicals. Extraction of G. lutea leaves was coupled to solid-phase adsorption by differently structured solids as a separation technology step, providing a selective isolation of both these secondary metabolites in good to excellent yields. Thus, the extraction of bitter secoiridoids can be achieved in an equivalent or improved way rather than processing the roots of G. lutea while preserving the biodiversity of the species.

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Pre-concentration of capsaicinoids from different cultivars of Capsicum annuum after extraction in heterogenous mixtures

Cited by 8 publications

References 39 publications

Genetic Regulation, Environmental Cues, and Extraction Methods for Higher Yield of Secondary Metabolites in Capsicum

Genetic Regulation, Environmental Cues, and Extraction Methods for Higher Yield of Secondary Metabolites in Capsicum

Solid‐phase adsorption methodologies of naturally occurring anthraquinones: A review

Leaves of Yellow Gentian (Gentiana lutea) as an Alternative Source of Bitter Secoiridoid Glycosides

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