Pre-conceptional and prenatal exposure to secondhand smoke and autism spectrum disorder: a national multi-center study in China

Lin, Lizi; Ou, Xiao-Xuan; Zhan, Xiaoling; Wang, Xin; Cai, Li; Li, Xiuhong; Jin, Jing; Dong, Guang‐Hui

doi:10.1007/s12519-022-00644-z

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…According to the 2019 GBD, SHS caused 1.3 million (95% UI: 1.0–1.6 in millions) deaths globally in 2019 14 . In recent years, growing evidence has shown that exposure to SHS is associated with numerous adverse health outcomes in both children and adults, including respiratory diseases, cardiovascular diseases, kidney diseases, diabetes, neurodevelopmental issues, and myopia in children 15 - 17 . As highlighted in the literature, even brief and temporary exposure to SHS can impact the development of human atherosclerosis 18 .…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019

Yang,

Zhang,

Sun

et al. 2024

Tob. Induc. Dis.

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Section: Discussionmentioning

confidence: 99%

Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019

Yang,

Zhang,

Sun

et al. 2024

Tob. Induc. Dis.

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Global trends of secondhand smoke exposure among young adolescents from 27 countries, 2003–2021: findings from the World Health Organization database

Lee,

Son,

Hong

et al. 2024

Sci Rep

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The issue of adolescent secondhand smoke (SHS) is globally significant, given that it serves as a preventable risk factor for disease prevalence and mortality rates among youth. This study evaluates trends in adolescent SHS across 27 countries from 2003 to 2021, aiming to identify global variations and sex-specific differences, providing insights for future policy recommendations. The data for this study were collected from the Global School-based Student Health Survey conducted by the World Health Organization, 2003–2021. The term SHS in this context denoted how many days people smoked in their presence for at least one day within the past 7 days. Linear regression models were employed to examine the trends of SHS exposure by country. In the present analysis based on 175,370 adolescents (male, 46.69%) aged between 13 and 15 years from 27 countries across the five continents, SHS decreased in 14 countries but exhibited an increasing trend in 3 countries (Benin [β, 3.20; 95% CI, 2.50–3.91]; Maldives [β, 0.93; 0.21–1.65]; Myanmar [β, 0.62; 0.29–0.95]). Significant increasing trends in females were observed in the Maldives (β, 1.18; 0.25–2.11) and Thailand (β, 0.36; 0.04–0.69) while males showed increasing trends in Kuwait (β, 1.90; 0.79-3.00) and Vanuatu (β, 1.95; 0.35–3.54). Our analysis of adolescents from 27 countries indicates that the majority of nations exhibited decreasing trends in SHS. This suggests that global efforts to prevent SHS are achievable through individual initiatives and international monitoring. However, the presence of increasing trends in certain countries underscores the need for stronger regulations and policies to address this issue. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-80713-7.

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Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment

Karatayev,

Collier,

Targoff

et al. 2024

IJMS

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Clinical studies demonstrate that the risk of developing neurological disorders is increased by overconsumption of the commonly used drugs, alcohol, nicotine and cannabis. These drug-induced neurological disorders, which include substance use disorder (SUD) and its co-occurring emotional conditions such as anxiety and depression, are observed not only in adults but also with drug use during adolescence and after prenatal exposure to these drugs, and they are accompanied by long-lasting disturbances in brain development. This report provides overviews of clinical and preclinical studies, which confirm these adverse effects in adolescents and the offspring prenatally exposed to the drugs and include a more in-depth description of specific neuronal systems, their neurocircuitry and molecular mechanisms, affected by drug exposure and of specific techniques used to determine if these effects in the brain are causally related to the behavioral disturbances. With analysis of further studies, this review then addresses four specific questions that are important for fully understanding the impact that drug use in young individuals can have on future pregnancies and their offspring. Evidence demonstrates that the adverse effects on their brain and behavior can occur: (1) at low doses with short periods of drug exposure during pregnancy; (2) after pre-conception drug use by both females and males; (3) in subsequent generations following the initial drug exposure; and (4) in a sex-dependent manner, with drug use producing a greater risk in females than males of developing SUDs with emotional conditions and female offspring after prenatal drug exposure responding more adversely than male offspring. With the recent rise in drug use by adolescents and pregnant women that has occurred in association with the legalization of cannabis and increased availability of vaping tools, these conclusions from the clinical and preclinical literature are particularly alarming and underscore the urgent need to educate young women and men about the possible harmful effects of early drug use and to seek novel therapeutic strategies that might help to limit drug use in young individuals.

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Pre-conceptional and prenatal exposure to secondhand smoke and autism spectrum disorder: a national multi-center study in China

Cited by 3 publications

References 39 publications

Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019

Global, regional, and national burden of ischemic heart disease attributable to secondhand smoke from 1990 to 2019

Global trends of secondhand smoke exposure among young adolescents from 27 countries, 2003–2021: findings from the World Health Organization database

Neurological Disorders Induced by Drug Use: Effects of Adolescent and Embryonic Drug Exposure on Behavioral Neurodevelopment

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