Pre-Diabetes Increases Stroke Risk in Patients With Nonvalvular Atrial Fibrillation

Kezerle, Louise; Tsadok, Meytal Avgil; Akriv, Amichay; Senderey, Adi Berliner; Bachrach, Asaf; Leventer‐Roberts, Maya; Haim, Moti

doi:10.1016/j.jacc.2020.12.030

Cited by 20 publications

(12 citation statements)

References 35 publications

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“…The included studies were published between 2011 and 2022. Three studies ( 19 , 21 , 27 ) were post-hoc analyses of randomized controlled trials, five studies ( 11 , 14 , 17 , 26 , 28 ) were retrospective designs, and others were prospective studies. Sample sizes ranged between 278 and 326,832, with 526,136 atrial fibrillation patients.…”

Section: Resultsmentioning

confidence: 99%

Impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation: A meta-analysis

Sun²,

Gong³

et al. 2022

Front. Endocrinol.

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ObjectiveTo determine the impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation (AF) by conducting a meta-analysis.MethodsPubMed and Embase databases were comprehensively searched for relevant studies publishing until May 19, 2022. Cohort studies or post-hoc analyses of clinical trials that investigated the association of diabetes mellitus with cardiovascular or all-cause mortality in AF patients were included.ResultsA total of 21 studies with 526,136 AF patients were identified. The pooled prevalence of diabetes mellitus in patients with AF was 26%. The summary multivariable-adjusted risk ratio (RR) of all-cause mortality was 1.37 (95% confidence intervals [CIs] 1.23–1.53) for patients with diabetes versus those without diabetes. Moreover, diabetes mellitus was also associated with an increased risk of cardiovascular mortality (RR 1.46; 95% CI 1.34–1.58). Stratified analyses suggested that the impact of diabetes on all-cause and cardiovascular mortality was consistently observed in each named subgroup.ConclusionThe presence of diabetes mellitus in patients with AF is associated with an increased risk of cardiovascular and all-cause mortality, even after adjustment for important confounding factors.

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Section: Resultsmentioning

confidence: 99%

Impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation: A meta-analysis

Sun²,

Gong³

et al. 2022

Front. Endocrinol.

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“…This process of capturing data into the registry reassures that a specific type of cancer diagnosed after the index date is not a recurrence or continuation of an original cancer diagnosed before the index date. A number of high-quality, population-based studies have been conducted based on the data retrieved from CHS database [ 10 – 12 ].…”

Section: Methodsmentioning

confidence: 99%

Increased risk of non-hematological cancer in young patients with aortic stenosis: a retrospective cohort study

et al. 2021

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Background We have previously reported an increased risk for non-hematological malignancies in young patients with moderate or severe aortic stenosis (AS). These findings were the result of a post-hoc analysis from a large echocardiography database and needed verification. Our aim was to determine, using a different study population, whether young patients with AS are at increased risk for cancer. Methods A large echocardiographic database was used to identify patients (age ≥ 20 years) with moderate or severe AS (study group) and patients without aortic stenosis (comparative group). The new occurrence of non-hematological malignancies was determined after the index date (first echo with moderate or severe AS or first recorded echo in the control group). Results The final study group included 7013 patients with AS and 98,884 without AS. During a median follow-up of 6.9 years (3.0–11.1) there were 10,705 new cases of non-hematological cancer. The crude incidence rate of cancer was higher in AS compared to non-AS patients (22.3 vs. 13.7 per 1000 patient-year, crude HR 1.58 (95%CI 1.46–1.71). After adjustment for relevant covariates, there was no difference between groups (HR 0.93, 95% CI 0.86–1.01). Only patients in the lowest age quartile (20–49.7 years), had an increased adjusted risk of cancer (HR 1.91, 95%CI 1.08–3.39). The HR for the risk of cancer associated with AS was inversely proportional to age (P < 0.001 for the interaction between AS and age). Conclusions Young patients with moderate or severe AS may have an increased risk for cancer. Cancer surveillance should be considered for young patients with AS.

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“…Insistió el ponente, el Dr. Pérez Martínez: tenemos que considerar la PRED un factor de RCV independiente. Expuso estudios [1][2][3] que respaldan esta relación, insistiendo en que no es necesario que la PRED evolucione a DM para desarrollar complicaciones o aumentar el RCV. Debemos actuar precozmente sobre la población con cribados en cualquier persona mayor de 35 años, como recomienda la última guía de práctica clínica (GPC) de la Asociación Americana de Diabetes (ADA); si se detectan cifras compatibles con PRED, se deben prescribir, que no recomendar, cambios del estilo de vida, ejercicio personalizado y fármacos, si son necesarios, manteniendo seguimiento cercano con el personal sanitario y buscando un buen control glucémico.…”

Section: Primera Mesa Deterioro Cognitivo (Dc) Y Diabetes Mellitus (Dm)unclassified

Reunión del grupo de Diabetes, Obesidad y Nutrición de la Sociedad Española de Medicina Interna (SEMI) en Córdoba

Sanz¹

2022

diabetpract

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Muchos de los seguidores de esta revista nos interesamos por reuniones científicas relacionadas con la diabetes, como las de la Sociedad Española de Diabetes (SED), la Sociedad Española de Endocrinología y Nutrición (SEEN), la Asociación Europea para el Estudio de la Diabetes (EASD) y la que comentamos en este artículo, la de la Sociedad Española de Medicina Interna (SEMI). El grupo de trabajo de Obesidad, Diabetes y Nutrición de la SEMI propuso en su reunión anual un programa interesante que abordó los nuevos tratamientos para la diabetes mellitus (DM) y sus comorbilidades, resaltando con especial interés la obesidad y la enfermedad renal crónica. También se habló de prediabetes, del deterioro cognitivo, de la fibrilación auricular, de los diferentes fenotipos de DM (conocerlos nos permitirá practicar la medicina de precisión) y de la dislipemia. Asimismo, se presentaron nuevos fármacos para el manejo de la DM y la obesidad. En este artículo se lleva a cabo una revisión de las sesiones más atractivas del evento.

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Pre-Diabetes Increases Stroke Risk in Patients With Nonvalvular Atrial Fibrillation

Cited by 20 publications

References 35 publications

Impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation: A meta-analysis

Impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation: A meta-analysis

Increased risk of non-hematological cancer in young patients with aortic stenosis: a retrospective cohort study

Reunión del grupo de Diabetes, Obesidad y Nutrición de la Sociedad Española de Medicina Interna (SEMI) en Córdoba

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