Pre‐diagnostic urinary 15‐F_2t‐isoprostane level and liver cancer risk: Results from the Shanghai Women's and Men's Health Studies

Abstract

Oxidative stress has been hypothesized to affect cancer development via various mechanisms, but the evidence from human is limited and inconclusive. 15-F -isoprostane (15-F -IsoP) is an accurate marker of oxidative stress in humans. Recent studies showed that the evidence of urinary 15-F -IsoP level correlating cancer risk is conflicting. We conducted a case-control study nested within two population-based cohort studies. Pre-diagnosis urine samples, collected at cohort enrollment, from 363 incident liver cancer cases and 725 individually matched controls, were used to determine the level of 15-F -IsoP by enzyme-linked immunosorbent assay. Conditional logistic regression model was used to estimate the odds ratio to measure the association between the urinary 15-F -IsoP level and liver cancer risk. We found that higher pre-diagnostic urinary 15-F -IsoP level was associated with an increased liver cancer risk, with an adjusted OR in males (OR = 8.84, 95% CI 2.74-28.60), which was significantly higher than those in females (OR = 1.75, 95% CI 0.70-4.42). HBsAg carriers with higher 15-F -IsoP had a significantly increased liver cancer risk (OR = 59.04, 95% CI 12.26, 284.30; OR = 92.55, 95% CI 34.83, 245.96) compared to non-carriers with lower 15-F -IsoP. High urinary 15-F -IsoP level was associated with high liver cancer risk, suggesting that 15-F -IsoP may be a promising biomarker for liver cancer risk. The result suggests that people with sero-positive HBsAg and higher level of 15-F -IsoP might be given a higher priority on future surveillance program of liver cancer.

A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways

“…Liver cancer is one of the leading causes of cancer death in the world [1][2][3][4]. Liver cancer is difcult to diagnose in the early stage, which will result in the death of patients.…”

“…Liver cancer is one of the leading causes of cancer death worldwide [1][2][3][4]. It is a heterogeneous, invasive, and drug-resistant malignant disease with poor prognosis [5][6][7], which is also the most common malignant tumor in the digestive system, with high mortality and low survival rate [3,8].…”

Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

“…Liver cancer is one of the six most common cancers in the world, with the seventhhighest incidence of cancer and the third-highest mortality rate, it is the leading cause of cancer death among men under 60 in China [7][8][9]. Primary liver cancer comprises hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and other rare tumors, notably fibrolamellar carcinoma and hepatoblastoma [10].…”