Pre-discharge iron status and its determinants in premature infants

Amin, Sanjiv B.; Scholer, Lori; Srivastava, Mohit

doi:10.3109/14767058.2012.685788

Cited by 13 publications

(10 citation statements)

References 28 publications

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“…The summary of the most relevant characteristics of the randomized and non-randomized studies included are shown in Table 3 and Table 4, respectively. Out of the 16 studies included, four were conducted in India [24,25,31,35], three were carried out in the Netherlands [30,32,33], four were performed in Sweden [26,27,28,29], three in the USA [36,38,39], one in Japan [37], and one in Brazil [34]; these studies were published between 2009 and 2017.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the randomization, this review includes six randomized studies [24,25,26,27,28,29] (being [26,27,28,29] results from the same original cohort) and 10 non-randomized studies [30,31,32,33,34,35,36,37,38,39]. Four of these studies were double-blind [26,27,28,29].…”

Section: Resultsmentioning

confidence: 99%

“…None of the included participants featured other pathologies apart from anemia. Most of the studies used iron supplements (specifically nine reports [24,25,26,27,28,29,34,36,38]) and the remaining studies did not use iron supplements [31,32,33,35,37,39].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, a lower birth weight was found in infants born with iron overload compared to those with normal iron status and latent ID status (serum ferritin ˂76 ng/mL or ˂170.7 pmol/L) [36]. Other studies did not find differences between iron supplemented groups and controls in mean weight, length, head circumference, or knee heel length at 6 months [26].…”

Section: Resultsmentioning

confidence: 99%

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Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review

2019

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Iron is an essential micronutrient that is involved in many functions in humans, as it plays a critical role in the growth and development of the central nervous system, among others. Premature and low birth weight infants have higher iron requirements due to increased postnatal growth compared to that of term infants and are, therefore, susceptible to a higher risk of developing iron deficiency or iron deficiency anemia. Notwithstanding, excess iron could affect organ development during the postnatal period, particularly in premature infants that have an immature and undeveloped antioxidant system. It is important, therefore, to perform a review and analyze the effects of iron status on the growth of premature infants. This is a transversal descriptive study of retrieved reports in the scientific literature by a systematic technique. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were adapted for the review strategy. The inclusion criteria for the studies were made using the PICO (population, intervention, comparison, outcome) model. Consequently, the systematic reviews that included studies published between 2008–2018 were evaluated based on the impact of iron status on parameters of growth and development in preterm infants.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review

2019

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“…Total body iron content, haemoglobin and ferritin concentrations are lower in pre-term infants (Halliday et al 1984;Singla et al 1985;Lackmann et al 1998), even in late pre-term infants born ≥34 weeks' gestational age (Ozdemir et al 2013;Yamada & Leone 2014). Between 20% and 50% of pre-term infants are either born iron deficient or will become deficient in early infancy (Amin et al 2010;Berglund et al 2010;Amin et al 2012;Uijterschout et al 2015;Akkermans et al 2016), with rates of 80-85% reported in pre-term infants exclusively breastfed or receiving inappropriate iron supplementation (Iwai et al 1986;Hall et al 1993).…”

Section: Prematurity and Low Birthweightmentioning

confidence: 99%

The neonatal period: A missed opportunity for the prevention of iron deficiency and its associated neurological consequences?

McCarthy

Kiely

2019

Nutrition Bulletin

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Iron deficiency is the most common micronutrient deficiency worldwide. Iron is essential for the development of multiple organ systems, most especially the developing brain. Iron deficiency, particularly during sensitive periods of brain development, such as in early childhood, is associated with long‐lasting adverse consequences for cognition, motor function and behaviour. Little consideration has been given to iron deficiency in newborn infants and its potential health consequences. Fetal iron accretion is compromised by pregnancy complications such as pre‐term birth and gestational diabetes mellitus, and our work has identified an increased risk of low iron stores at birth from maternal lifestyle factors such as smoking and obesity. Early‐life events, including Caesarean section delivery, further add to the cumulative risk of neonatal iron deficiency, which can persist throughout infancy into early childhood. While investigations into the long‐term neurological consequences of neonatal iron deficiency are limited, there is evidence of poorer memory, motor function and language ability in children born iron deficient. Recently, we also identified significant behavioural consequences of neonatal deficiency persisting from 2 to 5 years of age, with effects particularly apparent in ‘high‐risk’ children born to obese or smoking mothers or delivered by Caesarean section. Interventions targeting the fetal/neonatal period could therefore represent a key opportunity for the prevention of iron deficiency and its associated long‐term health consequences. A dual approach is required, comprising public health strategies targeting prevention, to improve health in women of reproductive age, and the development of screening strategies for the early detection of iron deficiency in newborn infants.

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High Prevalence of Iron Deficiency Despite Standardized High-Dose Iron Supplementation During Recombinant Erythropoietin Therapy in Extremely Low Gestational Age Newborns

Siddappa

Olson

Spector

et al. 2020

The Journal of Pediatrics

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Pre-discharge iron status and its determinants in premature infants

Abstract: Iron status at 35 weeks PMA is extremely variable and is predicted by prior erythrocyte transfusions or net erythrocyte balance in premature infants.

Cited by 13 publications

References 28 publications

Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review

Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review

The neonatal period: A missed opportunity for the prevention of iron deficiency and its associated neurological consequences?

High Prevalence of Iron Deficiency Despite Standardized High-Dose Iron Supplementation During Recombinant Erythropoietin Therapy in Extremely Low Gestational Age Newborns

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