2005
DOI: 10.1016/s0140-6736(05)17987-2
|View full text |Cite
|
Sign up to set email alerts
|

Pre-eclampsia

Abstract: Pre-eclampsia is a major cause of maternal mortality (15-20% in developed countries) and morbidities (acute and long-term), perinatal deaths, preterm birth, and intrauterine growth restriction. Key findings support a causal or pathogenetic model of superficial placentation driven by immune maladaptation, with subsequently reduced concentrations of angiogenic growth factors and increased placental debris in the maternal circulation resulting in a (mainly hypertensive) maternal inflammatory response. The final p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

22
1,370
3
28

Year Published

2010
2010
2023
2023

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 1,922 publications
(1,423 citation statements)
references
References 129 publications
22
1,370
3
28
Order By: Relevance
“…Of note, we only included cases without hypertensive disease or evidence of moderate or severe chorioamnionitis (confirmed by placental histopathology). We used an Australian birthweight chart to determine birthweight centiles for both cohorts 1 (See supplementary table 1).…”
Section: Tissue Collectionmentioning
confidence: 99%
“…Of note, we only included cases without hypertensive disease or evidence of moderate or severe chorioamnionitis (confirmed by placental histopathology). We used an Australian birthweight chart to determine birthweight centiles for both cohorts 1 (See supplementary table 1).…”
Section: Tissue Collectionmentioning
confidence: 99%
“…Preeclampsia is characterized by metabolic disturbances similar to those found in cardiovascular diseases and type 2 diabetes mellitus (T2DM) including endothelial dysfunction, inflammation, oxidative stress, insulin resistance and dyslipidemia [23] [24]. Healthy diet characterized by high intake of vegetables, fruits and vegetable oils was associated with reduced risk of preeclampsia in women [25]- [27].…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] It is characterized by maternal hypertension, proteinuria, and edema, which are major causes of maternal and fetal morbidity and mortality. 4,5 Although the pathogenesis of PE is poorly understood, it has been speculated that abnormal placentation is the primary cause of the disease.…”
mentioning
confidence: 99%