Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering

Zeng, Ning; Han, Yan; Wu, Yuhong; Zang, Mengqing; Largo, René D.; Chang, Edward I.; Schaverien, Mark V.; Yu, Peirong; Zhang, Qixu

doi:10.3389/fbioe.2023.1196521

Cited by 5 publications

(1 citation statement)

References 63 publications

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“…Cryopreservation enables the long-term survival of an allograft alongside a reduction in antigenicity. ReCTA assisted in fibrosis obliteration and maintained airway patency in the neo-trachea that, when pedicled with an adipose flap, can be easily incorporated into the tracheal construct to allow neovascularisation [27].…”

Section: Tracheal Grafting and Scaffoldingmentioning

confidence: 99%

Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication

Khalid,

Uchikov,

Hristov

et al. 2023

Medicina

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Background and Objectives: The aim of this review is to explore the recent surgical innovations in tracheal reconstruction by evaluating the uses of synthetic material fabrication when dealing with tracheomalacia or stenotic pathologies, then discussing the challenges holding back these innovations. Materials and Methods: A targeted non-systematic review of published literature relating to tracheal reconstruction was performed within the PubMed database to help identify how synthetic materials are utilised to innovate tracheal reconstruction. Results: The advancements in 3D printing to aid synthetic material fabrication have unveiled promising alternatives to conventional approaches. Achieving successful tracheal reconstruction through this technology demands that the 3D models exhibit biocompatibility with neighbouring tracheal elements by encompassing vasculature, chondral foundation, and immunocompatibility. Tracheal reconstruction has employed grafts and scaffolds, showing a promising beginning in vivo. Concurrently, the integration of resorbable models and stem cell therapy serves to underscore their viability and application in the context of tracheal pathologies. Despite this, certain barriers hinder its advancement in surgery. The intricate tracheal structure has posed a challenge for researchers seeking novel approaches to support its growth and regeneration. Conclusions: The potential of synthetic material fabrication has shown promising outcomes in initial studies involving smaller animals. Yet, to fully realise the applicability of these innovative developments, research must progress toward clinical trials. These trials would ascertain the anatomical and physiological effects on the human body, enabling a thorough evaluation of post-operative outcomes and any potential complications linked to the materials or cells implanted in the trachea.

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Section: Tracheal Grafting and Scaffoldingmentioning

confidence: 99%

Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication

Khalid,

Uchikov,

Hristov

et al. 2023

Medicina

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The Development of Lung Tissue Engineering: From Biomaterials to Multicellular Systems

Ma,

Wu,

2024

Adv Healthcare Materials

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The challenge of the treatment of end‐stage lung disease poses an urgent clinical demand for lung tissue engineering. Over the past few years, various lung tissue‐engineered constructs are developed for lung tissue regeneration and respiratory pathology study. In this review, an overview of recent achievements in the field of lung tissue engineering is proposed. The introduction of lung structure and lung injury are stated briefly at first. After that, the lung tissue‐engineered constructs are categorized into three types: acellular, monocellular, and multicellular systems. The different bioengineered constructs included in each system that can be applied to the reconstruction of the trachea, airway epithelium, alveoli, and even whole lung are described in detail, followed by the highlight of relevant representative research. Finally, the challenges and future directions of biomaterials, manufacturing technologies, and cells involved in lung tissue engineering are discussed. Overall, this review can provide referable ideas for the realization of functional lung regeneration and permanent lung substitution.

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Global Bibliometric and Visualized Analysis of Tracheal Tissue Engineering Research

Zhu,

Lu,

Shan

et al. 2024

Tissue Engineering Part B: Reviews

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Pre-epithelialized cryopreserved tracheal allograft for neo-trachea flap engineering

Cited by 5 publications

References 63 publications

Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication

Surgical Innovations in Tracheal Reconstruction: A Review on Synthetic Material Fabrication

The Development of Lung Tissue Engineering: From Biomaterials to Multicellular Systems

Global Bibliometric and Visualized Analysis of Tracheal Tissue Engineering Research

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