Pre-excitation syndrome in infants and children. Effect of digoxin, verapamil, and amiodarone.

Shahar, Eli; Barzilay, Zohar; Shem-Tov, Abraham; Shohet, I; Frand, Mira

doi:10.1136/adc.58.3.207

Cited by 11 publications

(5 citation statements)

References 25 publications

(4 reference statements)

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“…These observations corroborate those published so far [1,3,4,6,9] in which none of the side effects reported in adult patients have been observed, either in quality or in quantity, in children .…”

Section: Discussionsupporting

confidence: 95%

“…The effect on dysrhythmias is unquestionable and corroborates cases reported in the literature [1,3,4,[8][9][10] . The relapse that was observed in several children was due to a reduction in the dose, and sinus rhythm was restored by increasing it again (two children) or combining it with digoxin .…”

Section: Discussionsupporting

confidence: 89%

“…[3] is excessive for the initial dose and superior to the 10-to 15-mg/kg dose recommended by American authors [4,9] . The resultant maintenance dose also exceeds the average of 5 mg/kg suggested by Fiddle et al .…”

Section: Discussionmentioning

confidence: 99%

“…The experience in children [3,4,6,9], however, is very limited and, despite some good results [1,3,9, 101, the widespread use of this drug is viewed with great reservation due to the lack of guarantees as to its innocuousness [4,6] .…”

mentioning

confidence: 99%

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Effect on growth of children with cardiac dysrhythmias treated with amiodarone

Ardura

Bermejo

1988

Pediatr Cardiol

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SUMMARY . We report the results of treatment with amiodarone in nine children with dysrhythmias resistant to conventional drugs, namely, one with ventricular tachycardia, two with atrial tachycardia, one with junctional tachycardia, three with reciprocal rhythm tachycardia, and two with Wolff-Parkinson-White syndrome . The initial dose was 800 mg/1 .73 m2 , administered for two weeks, followed by half the dose for five days a week . The duration of the treatment varied from nine months to 19 months (mean duration, 13 months) . Patients were followed up for a period ranging between nine and 33 months (mean period, 17 months) . A complete remission was obtained in 56% of patients and partial success in 46% . The following side effects were detected : photosensitization in two ; effect on weight, height, growth velocity, and thyroid hormones in three, six, five, and six, respectively ; and acceleration in bone age in three . These effects were observed from two to nine months after the beginning of treatment . They persisted for 5-18 months after treatment had been suspended . The main side effect of amiodarone in children is presumably initial hypothyroidism, followed by a biological hyperthyroid reaction . For these reasons we suggest that amiodarone should be restricted as an alternative drug for resistant critical dysrhythmias and be used only for a limited period of two years .

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect on growth of children with cardiac dysrhythmias treated with amiodarone

Ardura

Bermejo

1988

Pediatr Cardiol

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“…16, No. 1, 1995 treatment of children with PSVT [19,27], with a reported efficacy of 93% in some series [21]. Nevertheless, the side effects of verapamil are well known: severe hypotension, bradycardia, apnea [7,15], and even cardiac arrest and sudden death [12].…”

Section: Discussionmentioning

confidence: 97%

Efficacy and safety of intravenous amiodarone for short-term treatment of paroxysmal supraventricular tachycardia in children

Soult¹,

Múñoz²,

López³

et al. 1995

Pediatr Cardiol

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The use of intravenous amiodarone was assessed during 23 episodes of paroxysmal supraventricular tachycardia in 15 children aged 9 days to 11 years. Five of the fifteen patients had congenital structural heart disease, and three had Wolf-Parkinson-White syndrome. Tachyarrhythmias were returned to sinus rhythm during 20 of the 23 episodes (87%). No major adverse effects occurred. Recurrence of tachycardia was not observed during short-term follow-up. In conclusion, intravenous amiodarone is an effective, safe antiarrhythmic drug for short-term treatment of supraventricular tachycardia in children.

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