Pre-existing arterial remodeling is associated with in-hospital and late adverse cardiac events after coronary interventions in patients with stable angina pectoris

Wexberg, Paul; Gyöngyösi, Mariann; Sperker, Wolfgang; Kiss, Katharina; Yang, Paul; Hassan, Ali; Pasterkamp, Gérard; Glogar, Dietmar

doi:10.1016/s0735-1097(00)00949-9

Cited by 44 publications

(37 citation statements)

References 22 publications

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“…Previous studies with coronary intervention have shown that patients with PR had the highest rate of major adverse cardiac events; in contrast, patients with NR may face high rates of in-hospital complications, including postinterventional dissection. 2,3 The consequences of SAMMPRIS suggest that the remodeling pattern may also be a prominent factor that influences the rate of periprocedural complications. In future studies, we will use a wall imaging technique to study the remodeling pattern of other intracranial arteries (such as the ICA) and will assess the influence of local remodeling patterns on periprocedural complications in patients with intracranial PTAS.…”

Section: Discussionmentioning

confidence: 99%

Morphologic Characteristics of Atherosclerotic Middle Cerebral Arteries on 3T High-Resolution MRI

Zhu

Lou

et al. 2013

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Morphologic Characteristics of Atherosclerotic Middle Cerebral Arteries on 3T High-Resolution MRI

Zhu

Lou

et al. 2013

AJNR Am J Neuroradiol

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“…Expansively remodeled arteries hide larger plaques than do constrictively remodeled arteries. [15][16][17][18][19] As mentioned, plaque area may be identical or smaller at the culprit lesion site compared with sites that have a normal lumen angiographically. 6 …”

Section: Plaquementioning

confidence: 97%

“…However, plaques in constrictively remodeled lesions appear to have a more stable phenotype associated with stable angina. [15][16][17][18][19]22 .…”

Section: Arterial Remodeling and Inflammatory Responses: A Double-edgmentioning

confidence: 99%

Expansive Arterial Remodeling: Location, Location, Location

Pasterkamp

Galis

Kleijn

2004

ATVB

Self Cite

118

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Abstract-The artery is a dynamic organ capable of changing its geometry in response to atherosclerotic plaque formation.Expansion of the vessel diameter retards luminal narrowing and is considered a compensatory response. However, the expansive remodeling response is a "wolf in sheep's clothes," because expansion is associated with the presence of inflammatory cells, proteolysis, and a thrombotic plaque phenotype. The prevalence and clinical presentation of expansively remodeled lesions may differ among vascular beds. However, it is evident that all types of atherosclerotic arterial expansive lesions share the presence of inflammatory cells and subsequent protease activities. The potential role of inflammation and protease activity in the development of the different remodeling modes is discussed. Key Words: remodeling Ⅲ atherosclerosis Ⅲ toll-like receptor Ⅲ inflammation Ⅲ compensatory enlargement P laque formation has long been considered the only determinant of atherosclerotic luminal narrowing. The arterial wall, however, is not a rigid tube, but rather an organ capable of overall reshaping in response to hemodynamic, mechanical, and biochemical stimuli. For instance, the increase in the circumference of the artery can partially or totally compensate for the encroachment of the lumen caused by formation of atherosclerotic plaques or by intimal hyperplasia after arterial injury. 1-3 However, the arterial wall may also respond with constrictive remodeling, thereby aggravating the luminal narrowing response 4,5 (Figure 1).Scientific interest in the role of arterial remodeling in occlusive arterial disease boomed with the upcoming use of the visualization technique of intravascular ultrasound (IVUS). With IVUS, it became apparent just how ubiquitously remodeling can prevent plaque from encroaching on the lumen and also how failure of an expansive remodeling response accelerates luminal stenosis in de novo atherosclerosis. The role of such geometrical remodeling response in relation to plaque formation is currently appreciated but has been traditionally strongly underestimated as a causal factor for arterial occlusive disease. It has recently become clear that the geometrical change in arterial size and plaque area may equally contribute to the luminal narrowing in atherosclerotic disease 6 (Figure 2). For instance, it is possible to demonstrate that in 5% of patients eligible for coronary intervention, the plaque mass at the culprit lesion is actually smaller than that located at the angiographically normal reference site, indicating that in such lesions the degree of luminal narrowing is determined by the differences in vessel size rather than by the plaque mass. 6 In this brief review, an overview of anatomical localization and local morphology of the different remodeling modes is given. We also discuss available results of mechanistic

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“…Positive remodeling was seen in 4 patients, but there was no clear difference here from frequencies previously reported for angina pectoris patients. [9][10][11][12] For greater clarification of lesion background characteristics of patients in the present study, it would have been preferable to conduct a comparative investigation with lesion backgrounds of patients testing positive in stress perfusion SPECT, but this was not undertaken here. In past Circulation Journal Vol.70, March 2006 investigations of IVUS findings in patients testing positive in stress perfusion SPECT, 13 the mean percentage area stenosis was 78.0±12.2%, revealing no difference with the results of our current study.…”

Section: Lesion Characteristics Assessed By Qca and Ivusmentioning

confidence: 99%

Study of the Predictors and Lesion Characteristics of Ischemic Heart Disease Patients With False Negative Results in Stress Myocardial Perfusion Single-Photon Emission Tomography

Fujimoto

Wagatsuma

Uchida

et al. 2006

Circ J

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Pre-existing arterial remodeling is associated with in-hospital and late adverse cardiac events after coronary interventions in patients with stable angina pectoris

Abstract: Adaptive remodeling is associated with a higher rate of MACE, target lesion restenosis and nontarget de novo stenosis. This finding may be due to differential responses of the adaptively remodeled vessel to revascularization and a generally accelerated course of systemic atherosclerosis.

Cited by 44 publications

References 22 publications

Morphologic Characteristics of Atherosclerotic Middle Cerebral Arteries on 3T High-Resolution MRI

Morphologic Characteristics of Atherosclerotic Middle Cerebral Arteries on 3T High-Resolution MRI

Expansive Arterial Remodeling: Location, Location, Location

Study of the Predictors and Lesion Characteristics of Ischemic Heart Disease Patients With False Negative Results in Stress Myocardial Perfusion Single-Photon Emission Tomography

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