Pre-Existing Cardiovascular Disease, Acute Kidney Injury, and Cardiovascular Outcomes in Hospitalized Blacks With Covid-19 Infection

Jegede, Opeyemi; Abe, Temidayo; Wagle, Bivek; Kỳ, Huỳnh; Hayes, Dolphurs; Campbell, Martin Luther; Mezue, Kenechukwu; Ram, Pradhum; Nwokike, Shirley I; Desai, Rupak; Effoe, Valery; Kpodonu, Jacques; Morgan, Jayne; Ofili, Elizabeth; Onwuanyi, Anekwe; Echols, Melvin R.

doi:10.1016/s0735-1097(21)04436-3

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…As patients enter the hyperinflammatory response phase, renal function gradually declines before other injuries, such as severe respiratory failure and ACI. 27 – 29 Accordingly, it should come as no surprise that impaired renal function is associated with other injuries, although further research must clarify the exact mechanism behind this association.…”

Section: Discussionmentioning

confidence: 99%

The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran

Soltani,

Hadadi,

Saleh

et al. 2023

JTHC

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Background: The present study aimed to investigate the association between acute cardiac injury (ACI) and outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19) in Iran. Methods: The current cohort study enrolled all consecutive hospitalized patients with COVID-19 (≥ 18 y) who had serum high-sensitivity cardiac troponin-I (hs-cTnT) measurements on admission between March 2020 and March 2021. ACI was determined as hs-cTnT levels exceeding the 99th percentile of normal values. Data on demographics, comorbidities, clinical and laboratory characteristics, and outcomes were collected from Web-based electronic health records. Results: The study population consisted of 1413 hospitalized patients with COVID-19, of whom 319 patients (22.58%) presented with ACI. The patients with ACI had a significantly higher mortality rate than those without ACI (48.28% vs 15.63%; P<0.001) within a mean follow-up of 218.86 days from symptom onset. ACI on admission was independently associated with mortality (HR, 1.44; P=0.018). In multivariable logistic regression, age (OR, 1.034; P<0.001), preexisting cardiac disease (OR, 1.49; P=0.035), preexisting malignancy (OR, 2.01; P=0.030), oxygen saturation reduced to less than 90% (OR, 2.15; P<0.001), leukocytosis (OR, 1.45; P=0.043), lymphopenia (OR, 1.49; P=0.020), reduced estimated glomerular filtration rates (eGFRs) (OR, 0.99; P=0.008), and treatment with intravenous immunoglobulin during hospitalization (OR, 4.03; P=0.006) were independently associated with ACI development. Conclusion: ACI occurrence on admission was associated with long-term mortality in our hospitalized patients with COVID-19. The finding further underscores the significance of evaluating ACI occurrence on admission, particularly in individuals more prone to ACI, including older individuals and those with preexisting comorbidities, reduced oxygen saturation, and increased inflammatory responses.

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Section: Discussionmentioning

confidence: 99%

The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran

Soltani,

Hadadi,

Saleh

et al. 2023

JTHC

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“…In addition to their more prevalent poor physical and mental health phenomena, the Black population bears a higher cost of health outcomes (i.e., a higher rate of diagnoses, premature death, chronic diseases, and mortality) ( CDC 2017 ; National Academies of Sciences, Engineering, and Medicine [NASEM] et al 2017 ). Empirical studies have found that Blacks are more likely to suffer from pre-existing health conditions and are more susceptible to hospitalization due to the increased prevalence of comorbidity (e.g., Egbuche et al 2021 ; Phillips et al 2021 ). Furthermore, they are disproportionately affected by heart disease, high blood pressure, diabetes, stroke, HIV, obesity, asthma, influenza, and pneumonia, of which many are leading causes of morbidity and mortality in the United States ( CDC 2020a ; Office of Minority Health Resource Center [OMHRC] 2021a , 2021b ).…”

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confidence: 99%

Racial Health Disparities and Black Heterogeneity in COVID-19: A Case Study of Miami Gardens

Paat

Orezzoli

Ngan

et al. 2023

Journal of Applied Social Science

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The COVID-19 pandemic is a critical public health concern that has disproportionately affected the Black community in the United States. The purpose of this study was to examine the risk and protective factors faced by residents in the City of Miami Gardens during the COVID-19 pandemic, with emphases placed on racial health disparities and Black heterogeneity. Using convenience and snowball sampling, quantitative and qualitative data for this study were collected via an anonymous online questionnaire using QuestionPro. Survey links were distributed by e-mail invitations with assistance from city officials to the residents of this predominantly Black city in Florida ( n = 83). Descriptive statistics and relevant qualitative responses are presented. Furthermore, a machine learning (ML) approach was used to select the most critical variables that characterized the two racial groups (Black versus non-Black participants) based on four ML feature selectors. Study findings offered important and interesting insights. Specifically, despite the greater prevalence of adopting measures to protect themselves and others from COVID-19, Black participants were more susceptible to activities that increased their COVID-19 risk levels. In addition, their rate of infection, particularly among the Afro-Caribbean ethnic group, was reported to be higher, indicating the need to further investigate the underlying conditions and root causes (including vaccine hesitancy and refusal) that contribute to their greater health disparities.

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Pre-Existing Cardiovascular Disease, Acute Kidney Injury, and Cardiovascular Outcomes in Hospitalized Blacks With Covid-19 Infection

Cited by 2 publications

References 40 publications

The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran

The Association between Acute Cardiac Injury and Outcomes of Hospitalized Patients with COVID-19: Long-term Follow-up Results from the Sina Hospital COVID-19 Registry, Iran

Racial Health Disparities and Black Heterogeneity in COVID-19: A Case Study of Miami Gardens

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