Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia
Zoya Mann,
Fayth Lim,
Suzie Verma
et al.
Abstract:Apical extrusion is a tissue-intrinsic process that allows epithelia to eliminate unfit or surplus cells. This is exemplified by the early extrusion of apoptotic cells, which is critical to maintain the epithelial barrier and prevent inflammation. Apoptotic extrusion is an active mechanical process, which involves mechanotransduction between apoptotic cells and their neighbours, as well as local changes in tissue mechanics. Here we report that the pre-existing mechanical tension at adherens junctions condition… Show more
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