Background
HIV pre-exposure prophylaxis (PrEP) uptake in women remains low. We developed a laboratory result-driven protocol to link women with a positive bacterial sexually transmitted infection (STI) to HIV PrEP at an urban, safety-net hospital.
Methods
Electronic health records of women with positive chlamydia, gonorrhea, and/or syphilis tests were reviewed and those eligible for PrEP were referred for direct or primary care provider-driven outreach. We assessed the proportion of women with STI who received PrEP offers, acceptance, and prescriptions before (July 1, 2018 - December 31, 2018) and after (January 1, 2019 – June 30, 2020) implementation to evaluate changes in the delivery of key elements of the PrEP care cascade (i.e., PrEP offers, acceptance, and prescribing) for women with STI after protocol implementation
Results
The proportion of women who received PrEP offers increased from 7.6% to 17.6% (p < 0.001). After multivariable adjustment, only the post-intervention period was associated with PrEP offer (OR 2.49, 95% CI 1.68-3.68). In subgroup analyses, PrEP offers increased significantly among non-Hispanic Black (OR 2.75, 95% CI 1.65-4.58) and Hispanic (OR 5.34, 95% CI 1.77-16.11) women but not among non-Hispanic white women (OR 1.49, 95% CI 0.54-4.05). Significant changes in PrEP acceptance and prescriptions were not observed in the sample overall.
Conclusion
A laboratory result-driven protocol was associated with a significant increase in PrEP offers to Black and Hispanic women with STI. Results provide concrete suggestions for health systems seeking to increase PrEP access and equity among women.