Pre-Exposure Rabies Vaccination Using Purified Chick Embryo Cell Rabies Vaccine Intradermally is Immunogenic and Safe

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

“…Similar findings have been observed in children aged 12-18 months receiving IM or ID Rabipur (1.0 or 0.1 ml, respectively) on Days 0,7 and 28 for PrEP, with concomitant administration of Japanese encephalitis vaccine [59]. Rabipur has also demonstrated immunogenicity in older children when administered by ID injection for PrEP [56,60]. Rabipur is generally well tolerated in children; reported typical adverse reactions in clinical trials included fever, tenderness, and pain and redness at the injection site.…”

A randomized open-labeled study to demonstrate the non-inferiority of purified chick-embryo cell rabies vaccine administered in the Zagreb regimen (2-1-1) compared with the Essen regimen in Chinese adults

“…[8][9][10][11][12] The immunogenicity, efficacy and safety of PCECV have been well established for both PrEP and PEP in previous clinical trials conducted in children and adults. 6,[11][12][13][14][15] Moreover, PCECV may to elicit long-lasting immunity even after 14 years in subjects receiving a single booster dose 2 years following primary 3-dose immunization. 16 The intramuscular PEP recommended by the WHO includes 2 alternative immunization regimens: the 5-dose "Essen" (1-1-1-1-1), with doses administered on each of Days 0, 3, 7, 14, and 28; and the abbreviated 4-dose "Zagreb" regimen (2-1-1), with 2 injections administered on Day 0, followed by one further dose on each Days 7, and 21.…”

Protecting Indian schoolchildren against rabies: Pre-exposure vaccination with purified chick embryo cell vaccine (PCECV) or purified verocell rabies vaccine (PVRV)

“…2 In addition to PEP, PreP with modern TCV like PCECV (Rabipur ® ) or PVRV (e.g., Verorab™) has long been utilized to protect people at risk of infection in industrialized nations and clinical studies have demonstrated the immunogenicity and safety of these vaccines. [18][19][20][21][22][23][24][25][26] Young children are a particularly vulnerable population for animal bites. Published data indicate that about 40 percent of documented dog bite cases in Asia occur in children, and children represent a large proportion of known rabies-associated deaths worldwide with up to 60% of documented rabies deaths occurring in young children.…”

“…They have been administered to children and adults traveling to rabies endemic areas and extensive studies have demonstrated their safety and immunogenicity. [18][19][20][21][22][23][24][25][26] Children playing outdoors are particularly vulnerable to dog bites since unvaccinated community dogs are commonly observed on the streets and on or around public and school playgrounds. Furthermore, children may not report animal bites to their parents or may delay reporting of bites.…”