Pre-hospital tracheal intubation in severe traumatic brain injury: a systematic review and meta-analysis

Anderson, Jordan; Ebeid, Annalize; Stallwood-Hall, Catrin

doi:10.1016/j.bja.2022.07.033

Cited by 12 publications

(1 citation statement)

References 44 publications

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“…The timeline of cellular response after the onset of either mild or severe TBI spans four phases: hyperacute (minutes to hours), acute (hours to days), subacute (days to weeks), and chronic (chronic, months and older) [5,6]. If the injury remains unresolved, the pathology continues and moves to the next stage, where the severity of brain damage continues to increase [7][8][9]. Currently, intracranial pressure (ICP) is the main clinical monitoring parameter for TBI.…”

Section: Introductionmentioning

confidence: 99%

Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury

Li,

Qi,

Zhang

et al. 2023

Optics in Health Care and Biomedical Optics XIII

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Section: Introductionmentioning

confidence: 99%

Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury

Li,

Qi,

Zhang

et al. 2023

Optics in Health Care and Biomedical Optics XIII

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Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single‐centre observational study

Meyer,

Dermendzhiev,

Hetz

et al. 2024

J cachexia sarcopenia muscle

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BackgroundBody composition parameters provide relevant prognostic significance in critical care cohorts and cancer populations. Published results regarding polytrauma patients are inconclusive to date. The goal of this study was to analyse the role of body composition parameters in severely injured trauma patients.MethodsAll consecutive patients requiring emergency tracheal intubation and mechanical ventilation before initial computed tomography (CT) at a level‐1 trauma centre over a 12‐year period (2008–2019) were reanalysed. The analysis included CT‐derived body composition parameters based upon whole‐body trauma CT as prognostic variables for 30‐day mortality, intensive care unit length of stay (ICU LOS) and mechanical ventilation duration.ResultsFour hundred seventy‐two patients (75% male) with a median age of 49 years, median injury severity score of 26 and 30‐day mortality rate of 22% (104 patients) met the inclusion criteria and were analysed. Regarding body composition parameters, 231 patients (49%) had visceral obesity, 75 patients had sarcopenia (16%) and 35 patients had sarcopenic obesity (7.4%). After adjustment for statistically significant univariable predictors age, body mass index, sarcopenic obesity, visceral obesity, American Society of Anesthesiologists classification ≥3, injury severity score and Glasgow Coma Scale ≤ 8 points, the Cox proportional hazard model identified sarcopenia as significant prognostic factor of 30‐day mortality (hazard ratio 2.84; 95% confidence interval 1.38–5.85; P = 0.004), which was confirmed in Kaplan–Meier survival analysis (log‐rank P = 0.006). In a subanalysis of 363 survivors, linear multivariable regression analysis revealed no significant associations of body composition parameters with ICU LOS and duration of mechanical ventilation.ConclusionsIn a multivariable analysis of mechanically ventilated trauma patients, CT‐defined sarcopenia was significantly associated with 30‐day mortality whereas no associations of body composition parameters with ICU LOS and duration of mechanical ventilation were observed.

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Coronary artery calcification detected by initial polytrauma CT in severely injured patients: retrospective single-center cohort study

Meyer,

Dermendzhiev,

Hetz

et al. 2024

Eur J Trauma Emerg Surg

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Objectives Coronary artery calcifications detected by computed tomography (CT) provide prognostic relevance for vascular disorders and coronary heart disease, whereas their prognostic relevance in severely injured trauma patients remains unclear. Material and Methods All consecutive trauma patients requiring emergency tracheal intubation before initial CT at a level-1 trauma center and admission to the intensive care unit (ICU) over a 12-year period (2008–2019) were reanalyzed. The Weston score, a semiquantitative method to quantify coronary calcifications, was evaluated as a prognostic variable based upon whole-body trauma CT analysis. Results Four hundred fifty-eight patients (74.6% male) with a median age of 49 years, median injury severity score of 26 points, 24-h mortality rate of 7.6%, and 30-day mortality rate of 22.1% met the inclusion criteria and were analyzed. Coronary artery calcification was present in 214 patients (46.7%). After adjustment for confounding factors, the Weston score was an independent predictor for 24-h mortality (hazard ratio, HR 1.19, 95% confidence interval, CI 1.06–1.32, p = .002) and 30-day mortality (HR 1.09, 95% CI 1.01–1.17, p = .027). In a subanalysis of 357 survivors, the Weston score was significantly associated with ICU length of stay (LOS) (beta weight 0.89, 95% CI 0.3–1.47, p = .003) but not with mechanical ventilation duration (beta weight 0.05, 95% CI -0.2–0.63, p = .304). Conclusion CT-detected coronary calcification was a significant prognostic factor for 24-h- and 30-day-mortality in severely injured trauma patients requiring tracheal intubation, and influenced ICU LOS in survivors.

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Pre-hospital tracheal intubation in severe traumatic brain injury: a systematic review and meta-analysis

Cited by 12 publications

References 44 publications

Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury

Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury

Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single‐centre observational study

Coronary artery calcification detected by initial polytrauma CT in severely injured patients: retrospective single-center cohort study

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