Pre-Implantation Development

Austin, Charles

doi:10.1007/978-94-011-1286-4_2

Cited by 3 publications

(3 citation statements)

References 343 publications

(272 reference statements)

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“…Sob condições natu rais in vivo, muito poucos espermatozóides chegam nas proxi midades do oócito no momento da fe rtilização. Austin (1960) fo i um dos primeiros a descrever que o espermatozóide preci sa estar "capacitado" para que possa penetrar no cumulus. No entanto, para que sejam capazes de penetrar as células do cumulus deverão apresentar acrossomas intactos.…”

Section: Eventos Que Precedem O Processo De Fertilizaçãounclassified

Understanding the fertilization process ... (from sperm capacitation to fusion between plasma membranes) Part 1

Rossi-Ferragut,

Rocha,

laconelli Jr

et al. 2001

JBRA

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The human reproduction needs to spermatozoa and metaphase II oocyte fusion, during fe rtilization. During this, molecular, genetic, enzymatic and mechanical complex processes must be occur, leading embryonic and after, fetal development allowing health baby home. This first part of review focussed initials steps in in vivo fertilization process, beginning with capacitation until plasma membrane fusion.

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Section: Eventos Que Precedem O Processo De Fertilizaçãounclassified

Understanding the fertilization process ... (from sperm capacitation to fusion between plasma membranes) Part 1

Rossi-Ferragut,

Rocha,

laconelli Jr

et al. 2001

JBRA

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“…Analytical study of mammalian fertilization began in the middle of the last century after Austin [ 1 ] clarified every step of fertilization by his careful microscopic examination, and Austin [ 2 ] and Chang [ 3 ] co-discovered that mammalian spermatozoa require capacitation before they become fertilization competent [ 4 ]. Thibault et al [ 5 ] first saw a spermatozoon within the egg (of rabbit) after in vitro insemination using capacitated spermatozoa.…”

Section: Introductionmentioning

confidence: 99%

Mysteries and unsolved problems of mammalian fertilization and related topics

Yanagimachi

2022

Biology of Reproduction

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Mammalian fertilization is a fascinating process that leads to the formation of a new individual. Eggs and sperm are complex cells that must meet at the appropriate time and position within the female reproductive tract for successful fertilization. I have been studying various aspects of mammalian fertilization over 60 years. In this review, I discuss many different aspects of mammalian fertilization, some of my laboratory’s contribution to the field, and discuss enigmas and mysteries that remain to be solved.

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“…Other than these data, knowledge is very limited regarding the potential role of EDNs and other vasomodulatory factors in the uterus and utero-placental (Ut-Pl) units during implantation and placentation in the canine species. However, especially when the invasive, endotheliochorial type of canine placentation is taken into consideration, adequate proliferation and invasion of trophoblasts must be critical for the species-specific decidualization, implantation and placentation in dogs [ 14 , 15 , 16 ].…”

mentioning

confidence: 99%

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation

Gram

Boos

Kowalewski

2017

Journal of Reproduction and Development

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Utero-placental (Ut-Pl) angiogenesis and blood flow are fundamental for successful outcome of pregnancy. They are controlled by numerous vasodilator and vasoconstrictor systems such as endothelins (EDNs) and the renin angiotensin system. Dogs possess an invasive type of placentation, classified as endotheliochorial. Despite increasing knowledge regarding canine Ut-Pl function, little information exists on uterine and placental vascular activity during initiation, maintenance and termination of pregnancy in this species. The current study investigated expression of EDNs and their receptors (EDNRA and EDNRB) in the pre-implantation uterus and Ut-Pl compartments during gestation and at normal parturition, as well as in mid-pregnant dogs treated with the antigestagen aglepristone. The Ut-Pl mRNA expression of EDN1 and EDNRA was constant until mid-gestation and increased significantly during prepartum luteolysis. In contrast, EDN2 was highest pre-implantation and decreased following placentation, remaining low thereafter. Expression of the EDN-activating enzyme ECE1 and mRNA of EDNRB increased towards mid-gestation and was further elevated at prepartum luteolysis. Antigestagen treatment resulted in increased levels of EDN1 and EDNRA. At the cellular level, the uterine expression of EDN1, ECE1 and EDNRB was found predominantly in the endometrial surface and glandular epithelial cells; uterine signals for EDNRA were weak. In Ut-Pl all targets were mainly localized in the placenta fetalis, with syncytiotrophoblast staining stronger for ECE1 and EDNRB. In contrast, EDNRA stained strongly at the base of the placental labyrinth. Expression and localization of EDNs (EDN1, -2), EDN receptors and ECE1 in the placenta fetalis suggests their involvement in the trophoblast invasion and proliferation.

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Pre-Implantation Development

Cited by 3 publications

References 343 publications

Understanding the fertilization process ... (from sperm capacitation to fusion between plasma membranes) Part 1

Understanding the fertilization process ... (from sperm capacitation to fusion between plasma membranes) Part 1

Mysteries and unsolved problems of mammalian fertilization and related topics

Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation

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