Pre-irradiation tumour volumes defined by MRI and dual time-point FET-PET for the prediction of glioblastoma multiforme recurrence: A prospective study

Harat, Maciej; Małkowski, Bogdan; Makarewicz, Roman

doi:10.1016/j.radonc.2016.06.004

Cited by 42 publications

(33 citation statements)

References 39 publications

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“…A Polish study demonstrated the discordance between gross tumor volume (GTVs) delineated from MRI as compared to 18F-fluoroethylthyrosine-PET (FET-PET), a functional imaging modality; FET-PET was better associated with the site of eventual failure, suggesting that traditional target volumes may not be adequate. 26 ADC maps generated from diffusion imaging can identify areas of restricted diffusion that may predict for areas of eventual recurrence with high concordance; 27,28 for adequate post-operative recovery. Radiotherapy planning includes registration (aka "fusion") of the post-operative MRI (T1CE and FLAIR sequences) with the planning simulation CT, which allows for delineation of the FLAIR abnormality and residual enhancement in treatment planning.…”

Section: Mr Imaging To Define the At Risk Target Volumes And Organs Amentioning

confidence: 99%

Advanced Magnetic Resonance Imaging in Glioblastoma: A Review

Shukla¹,

Alexander²,

Bakas³

et al. 2018

JHN Journal

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Section: Mr Imaging To Define the At Risk Target Volumes And Organs Amentioning

confidence: 99%

Advanced Magnetic Resonance Imaging in Glioblastoma: A Review

Shukla¹,

Alexander²,

Bakas³

et al. 2018

JHN Journal

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“…Geographical error is frequently cited as one of the main reasons for failure of dose escalation trials. dtpFET-PET can be used to more accurately detect and map infiltration ( 12 ). Here, we show with molecular imaging that increased, higher dose coverage of dtpFET-PET tumor regions is positively correlated with time to progression.…”

Section: Discussionmentioning

confidence: 99%

“…The dosimetric analysis was performed on 29 consecutive patients (mean age 52.4 ± 19.2) prospectively recruited to a previously published study analyzing the role of dtpFET-PET on treatment planning of newly diagnosed GBM ( 12 ). Main inclusion criteria were as follows: histological confirmation of tumor, WHO performance status 0–2, no previous radiation, aged 18 years or older, concurrent temozolomide treatment, and Karnofsky performance status >60.…”

Section: Methodsmentioning

confidence: 99%

“…Details of dtpFET-PET and MRI imaging and target volume definitions are described in Ref. ( 12 ). The medical physicist in time of treatment planning was blinded to PET results.…”

Section: Methodsmentioning

confidence: 99%

“…Dynamic PET with FET is recommended for grading gliomas, prognostication of untreated gliomas, and differentiation of metastasis and recurrence from radiation-induced changes ( 11 ). We recently showed that FET-PET at dual time points (dtpFET-PET) precisely defines the most probable sites of failure ( 12 ). Moreover, biological tumor volumes defined by FET-PET, especially in dual time point acquisition compared with T1-weighted sequences, are significantly larger.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Glioblastoma Dose Volume Parameters Measured by Dual Time Point Fluoroethylthyrosine-PET and Clinical Outcomes

Harat

Małkowski²,

Wiatrowska

et al. 2018

Front. Neurol.

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Glioblastoma multiforme (GBM) is highly invasive. Despite irradiation with wide margins, GBM usually recurs in-field. Recent in vitro data have suggested that progression might be promoted by sublethal irradiation. Fluoroethylthyrosine-PET (FET-PET) can be used to detect glioblastoma invasion not apparent on MRI. We therefore performed a retrospective analysis of a prospective clinical study to examine whether glioblastoma outcomes depend on dose volume parameters measured by MRI and FET-PET. Twenty-three patients were prospectively recruited to a study examining the role of dual time point FET-PET in the treatment planning of GBM radiotherapy. The dose delivered to the site of recurrence was subdivided into suboptimal-dose (SOD) and high-dose (HD) areas. Types of progression were defined for correlation with dosimetric parameters including V100% of gross tumor volume (GTV)PET, GTVPETMRI, and GTVMRI. The HD area did not cover the entire GTVPETMRI in any case. Recurrences were significantly more frequent in the SubD area (chi-squared test, p = 0.004). There was no relationship between increasing dose volume and progression. The V100% for GTVPET and progression-free survival (PFS) was positively correlated (Spearman’s rho 0.417; p = 0.038). Progression is more common in areas with suboptimal dosing. Dose heterogeneity within GTVPET may be responsible for shorter PFS.

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Biological tumour volumes of gliomas in early and standard 20–40 min 18F-FET PET images differ according to IDH mutation status

Winkelmann

Suchorska

Giese

et al. 2018

Eur J Nucl Med Mol Imaging

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BTVs delineated in early and standard summation images differed significantly in more than half of gliomas. While the standard summation images seem appropriate for delineation of LGG as well as IDH-mutant gliomas, a remarkably high percentage of HGG and, particularly, IDH-wildtype gliomas were depicted with significantly larger volumes in early summation images. This finding might be of interest for optimization of treatment planning (e.g. radiotherapy) in accordance with the individual IDH mutation status.

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Pre-irradiation tumour volumes defined by MRI and dual time-point FET-PET for the prediction of glioblastoma multiforme recurrence: A prospective study

Cited by 42 publications

References 39 publications

Advanced Magnetic Resonance Imaging in Glioblastoma: A Review

Advanced Magnetic Resonance Imaging in Glioblastoma: A Review

Relationship between Glioblastoma Dose Volume Parameters Measured by Dual Time Point Fluoroethylthyrosine-PET and Clinical Outcomes

Biological tumour volumes of gliomas in early and standard 20–40 min 18F-FET PET images differ according to IDH mutation status

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