Pre-metazoan origin of neuropeptide signalling

Yáñez-Guerra, Luis Alfonso; Thiel, Daniel; Jékely, Gáspár

doi:10.1101/2021.11.19.469228

Cited by 2 publications

(2 citation statements)

References 70 publications

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“…They exist in numerous forms, which are structurally and functionally very diverse, and they are known to play multiple roles in developmental processes, as well as in regulation of most aspects of physiology and behaviour [6,18,30,[46][47][48][49][50]. Peptides are evolutionarily ancient and are used for signalling also in organisms that lack a nervous system [51][52][53]. They are encoded by genes that give rise to precursor proteins from which the mature peptides are enzymatically cleaved (see [50,[54][55][56]).…”

Section: Peptides In Synaptic Paracrine and Hormonal Signallingmentioning

confidence: 99%

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

Nässel

Zandawala

2022

Open Biol.

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Plasticity in animal behaviour relies on the ability to integrate external and internal cues from the changing environment and hence modulate activity in synaptic circuits of the brain. This context-dependent neuromodulation is largely based on non-synaptic signalling with neuropeptides. Here, we describe select peptidergic systems in the Drosophila brain that act at different levels of a hierarchy to modulate behaviour and associated physiology. These systems modulate circuits in brain regions, such as the central complex and the mushroom bodies, which supervise specific behaviours. At the top level of the hierarchy there are small numbers of large peptidergic neurons that arborize widely in multiple areas of the brain to orchestrate or modulate global activity in a state and context-dependent manner. At the bottom level local peptidergic neurons provide executive neuromodulation of sensory gain and intrinsically in restricted parts of specific neuronal circuits. The orchestrating neurons receive interoceptive signals that mediate energy and sleep homeostasis, metabolic state and circadian timing, as well as external cues that affect food search, aggression or mating. Some of these cues can be triggers of conflicting behaviours such as mating versus aggression, or sleep versus feeding, and peptidergic neurons participate in circuits, enabling behaviour choices and switches.

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Section: Peptides In Synaptic Paracrine and Hormonal Signallingmentioning

confidence: 99%

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

Nässel

Zandawala

2022

Open Biol.

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“…Neuropeptides and peptide hormones constitute ancient signaling molecules that are genetically encoded on precursors that give rise to one or more bioactive peptides acting on different types of membrane receptors. Bioactive peptides are present already in organisms that lack a nervous system, such as for instance sponges [ 6 ] and the Placozoan Trichoplax adhaerens , [ 7 ]. The latter small marine animal utilizes a small number of peptides, derived from five precursors, to regulate simple behaviors associated with locomotion and food intake [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression

Nässel

2022

Cell. Mol. Life Sci.

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Neuropeptides are the most diverse messenger molecules in metazoans and are involved in regulation of daily physiology and a wide array of behaviors. Some neuropeptides and their cognate receptors are structurally and functionally well conserved over evolution in bilaterian animals. Among these are peptides related to gastrin and cholecystokinin (CCK). In mammals, CCK is produced by intestinal endocrine cells and brain neurons, and regulates gall bladder contractions, pancreatic enzyme secretion, gut functions, satiety and food intake. Additionally, CCK plays important roles in neuromodulation in several brain circuits that regulate reward, anxiety, aggression and sexual behavior. In invertebrates, CCK-type peptides (sulfakinins, SKs) are, with a few exceptions, produced by brain neurons only. Common among invertebrates is that SKs mediate satiety and regulate food ingestion by a variety of mechanisms. Also regulation of secretion of digestive enzymes has been reported. Studies of the genetically tractable fly Drosophila have advanced our understanding of SK signaling mechanisms in regulation of satiety and feeding, but also in gustatory sensitivity, locomotor activity, aggression and reproductive behavior. A set of eight SK-expressing brain neurons plays important roles in regulation of these competing behaviors. In males, they integrate internal state and external stimuli to diminish sex drive and increase aggression. The same neurons also diminish sugar gustation, induce satiety and reduce feeding. Although several functional roles of CCK/SK signaling appear conserved between Drosophila and mammals, available data suggest that the underlying mechanisms differ.

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Pre-metazoan origin of neuropeptide signalling

Cited by 2 publications

References 70 publications

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression

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