Pre-OPerative accelerated radiotherapy for early stage breast cancer patients (POPART): A feasibility study

Mulliez, Thomas; Miedema, Geertje; Parijs, Hilde Van; Hottat, Nathalie; Vassilieff, Maud; Gillet, Evy; Baeyens, Luc; Voordeckers, Mia; Coelmont, Jolien; Besse‐Hammer, Tatiana; Gevaert, Thierry; Nazac, André; Ridder, Mark De

doi:10.1016/j.radonc.2022.02.033

Cited by 13 publications

(7 citation statements)

References 21 publications

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“…Fewer treatment fractions streamline healthcare logistics, decrease expenses, minimize waiting times, lower the risk of treatment interruption, and enhance patient comfort by reducing in-hospital time and treatment burden. This ultimately improves patient access to advanced radiation therapy [35] , [36] , [37] .…”

Section: Discussionmentioning

confidence: 99%

Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results

Ratosa,

Montero,

Ciervide

et al. 2024

Clinical and Translational Radiation Oncology

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Section: Discussionmentioning

confidence: 99%

Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results

Ratosa,

Montero,

Ciervide

et al. 2024

Clinical and Translational Radiation Oncology

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“…Between March 2017 and November 2020, DWI before and after preoperative radiotherapy was evaluated in a series of 19 patients with 22 early BCa enrolled in this prospective, single-center pilot study (ancillary study to the POPART study) [ 3 ]. The inclusion criteria were age over 18 years, a pretherapeutic standardized breast 3T MRI, stage cT1-2N0M0, Luminal A or B, candidate for breast-conserving surgery, N0-status confirmed by lymph node cytology, and a standardized breast 3T MRI after radiotherapy.…”

Section: Methodsmentioning

confidence: 99%

“…Formerly, whole-breast irradiation with boost was delivered in six to seven weeks [ 2 ]. Preoperative radiotherapy followed by immediate breast-sparing surgery is a new therapeutic approach under study in our institution with potential benefits, such as a more precise targeting of the tumor and a decrease in overall treatment time with positive effect on quality of life and reduction in health care costs [ 3 ]. This therapeutic management could also avoid delays in delivering radiotherapy in case of post-operative wound complications.…”

Section: Introductionmentioning

confidence: 99%

Diffusion-Weighted MRI in the Evaluation of Early-Stage Breast Cancer Treated with a Short Preoperative Radiotherapy: Preliminary Results

Hottat¹,

Jani²,

Badr³

et al. 2023

Journal of the Belgian Society of Radiology

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Objective: To assess tumor response with diffusion-weighted MRI (DW-MRI) after a short preoperative radiotherapy in early-stage breast cancer (BCa). Materials and Methods:This was a prospective, single-center pilot study. 3T-MRI were performed before and after radiotherapy. The longest diameter (LD) and the apparent diffusion coefficient (ADC) value of a region of interest (ROI) of the tumors were recorded. Histopathology and immunohistochemistry, including the Ki-67 index of the core biopsy and of the surgical specimen, were the reference standards.Results: Nineteen patients with 22 early-stage BCa were included. The mean ROI ADC value was 1.093 ± 0.278 × 10 -3 mm 2 /s before radiotherapy and 1.490 ± 0.429 × 10 -3 mm 2 /s (p-value < 0.001) after radiotherapy. The Ki-67 index was 9.2 ± 9.1% at the percutaneous biopsy before radiotherapy and 4.9 ± 7.5% (p-value = 0.005) after radiotherapy at the surgical specimen. After neoadjuvant radiotherapy, a 4.7% decrease in LD and a 36.3% increase in ROI-ADC of the tumors were measured at MRI and a 46.7% decrease in Ki-67 index was observed at histology of the surgical specimen in comparison with the percutaneous core biopsy. Conclusion:In early-stage BCa, a significant increase in ROI-ADC at DWI and a significant decrease in Ki-67 index were observed after a short preoperative radiotherapy, suggesting early tumor response.

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“…(1) La radioterapia ha sido una herramienta muy empleada en el tratamiento del cáncer de mama, con beneficios claros; la reducción del riesgo de recurrencia (-2,9 %) y disminución de la muerte por esa causa en aproximadamente una sexta parte después de la cirugía conservadora de mama. (2,3) La RT ha tenido una gran evolución, tanto en el esquema de administración (el hipofraccionamiento y ultra hipofraccionamiento), en los métodos o equipos de su administración, y en las técnicas de preservación cardiaca y disminución de daño en órganos no diana, a través de las modalidades IMRT (Intensity Modulated Radiotherapy), VMAT (Volumetric Modulated), 3D 3 .…”

Section: Introductionunclassified

Radioterapia preoperatoria en cáncer de mama como estrategia terapéutica, a propósito de un caso

Bahsas,

Solorzano,

Villegas

et al. 2024

Rev Digit Postgrado

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Múltiples estrategias terapéuticas se han desarrollado con el objetivo de optimizar el tratamiento del cáncer de mama, especialmente antes de ir a quirófano, desde la introducción de la quimioterapia preoperatoria por Fisher. Una de estas ha sido la radioterapia, la cual tiene beneficios claros en esa patología, pues reduce a la mitad el riesgo de recurrencia, y disminuye la muerte por cáncer de mama en aproximadamente una sexta parte después de cirugía conservadora. Aunque no se suele considerar antes de la cirugía, el uso de radioterapia preoperatoria en cáncer de mama, no es nuevo, y se ha demostrado que esta alternativa terapéutica es factible, bien tolerada y asociada a una tasa de respuesta patológica completa del 10 % - 40%. Se presenta el caso de una paciente con cáncer de mama metastásico, quien recibió múltiples esquemas de quimioterapia y a quien se le planteó radioterapia preoperatoria, recibiendo la misma con muy buena respuesta, sin aumentar la dificultad técnica para la realización de la intervención quirúrgica, y sin complicaciones asociadas a la herida operatoria. En la actualidad, existen pocos estudios clínicos sobre radioterapia preoperatoria, y su efecto en las pacientes con cáncer de mama localmente avanzado, es controvertido. Al observar en la biopsia definitiva respuesta patológica completa, es un indicio de cómo la radioterapia preoperatoria en cáncer de mama podría ser una opción en casos complejos con poca respuesta a la terapia convencional.

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Pre-OPerative accelerated radiotherapy for early stage breast cancer patients (POPART): A feasibility study

Cited by 13 publications

References 21 publications

Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results

Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results

Diffusion-Weighted MRI in the Evaluation of Early-Stage Breast Cancer Treated with a Short Preoperative Radiotherapy: Preliminary Results

Radioterapia preoperatoria en cáncer de mama como estrategia terapéutica, a propósito de un caso

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