Pre-operative embolization and excision of vagal schwannoma with rich vascular supply

Xu, Tao; Liu, Yue; Liu, Siyuan; Li, Zheng

doi:10.1097/md.0000000000028760

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…Interestingly, several studies have shown that understanding the eccentric growth pattern of the tumor and the anatomical features of the recurrent laryngeal and non-laryngeal reflexes can help surgeons to protect nerves as much as possible to preserve good vocal function after surgery [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

et al. 2023

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Background and Objectives: Clinical management of vagal schwannoma is a real diagnostic and therapeutic challenge because the medical history and clinical examination are often non-specific and vagal nerve injury following surgical resection still represents an unsolved problem. The aim of this paper is to provide a case series along with a diagnostic and therapeutic algorithm for vagal schwannoma of the head and neck, combining our experience with clinical evidence available in the literature. Materials and Methods: We retrospectively analyzed a series of patients affected by vagal schwannoma who were treated between 2000 and 2020. In addition, a review of the literature on vagal schwannoma management was conducted. Based on the cases described and the literature review, we made a diagnostic and therapeutic algorithm for the management of vagal schwannoma. Results: We were able to identify 10 patients affected by vagal schwannoma and treated between 2000 and 2020. All patients presented with a painless, mobile, slow-growing lateral neck mass with onset varying from a few months to years. The preoperative diagnostic workup included ultrasound (US) in nine cases, computed tomography (CT) with contrast in six patients and magnetic resonance imaging (MRI) of the neck in seven cases. All patients included in this study were surgically treated. Conclusions: Vagal schwannoma management represents a true challenge for clinicians and surgery is currently the most effective therapeutic strategy. A multidisciplinary approach through the collaboration of otolaryngologist with other specialists is desirable to develop a tailored treatment plan for the patient.

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Section: Discussionmentioning

confidence: 99%

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

et al. 2023

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Quantification of vessel separation using the carotid-jugular angle to predict the nerve origin of neck peripheral nerve sheath tumours: a pooled analysis of cases from the literature and a single-center cohort

Wong

Huang

Chuang

et al. 2023

International Journal of Surgery

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Background: Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumours (PNSTs). Accurate preoperative identification of the nerve origin (NO) can improve surgical outcomes and patient counselling. Material and methods: This study was a retrospective cohort and quantitative analysis of the literature. The authors introduced a parameter, the carotid-jugular angle (CJA), to differentiate the NO. A literature review of neck PNST cases from 2010 to 2022 was conducted. The CJA was measured from eligible imaging data, and quantitative analysis was performed to evaluate the ability of the CJA to predict the NO. External validation was performed using a single-centre cohort from 2008 to 2021. Results: In total, 17 patients from our single-centre cohort and 88 patients from the literature were analyzed. Among them, 53, 45, and 7 patients had sympathetic, vagus, and cervical nerve PNSTs, respectively. Vagus nerve tumours had the largest CJA, followed by sympathetic tumours, whereas cervical nerve tumours had the smallest CJA (P<0.001). Multivariate logistic regression identified a larger CJA as a predictor of vagus NO (P<0.001), and receiver operating characteristic (ROC) analysis showed an area under the curve (AUC) of 0.907 (0.831–0.951) for the CJA to predict vagus NO (P<0.001). External validation showed an AUC of 0.928 (0.727–0.988) (P<0.001). Compared with the AUC of the previously proposed qualitative method (AUC=0.764, 0.673–0.839), that of the CJA was greater (P=0.011). The cut-off value identified to predict vagus NO was greater than or equal to 100°. Receiver operating characteristic analysis showed an AUC of 0.909 (0.837–0.956) for the CJA to predict cervical NO (P<0.001), with a cut-off value less than 38.5°. Conclusions: A CJA greater than or equal to 100° predicted a vagus NO and a CJA less than 100° predicted a non-vagus NO. Moreover, a CJA less than 38.5 was associated with an increased likelihood of cervical NO.

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Cervical vagal nerve schwannoma induced arrhythmia: a rare case report and literature review

Chen

et al. 2022

BMC Neurol

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Background Schwannomas are benign tumors deriving from the sheath of cranial and peripheral nerves. The vagus nerve is comprised of a complex neuro-endocrine-immune network that maintains homeostasis, most tracts of it play a role in parasympathetic activity. We present an example of a rare cervical vagal schwannoma case accompanied by arrhythmia. Case presentation A 35-year-old female patient with a left cervical vagus schwannoma and ventricular arrhythmia underwent schwannoma resection in the operating room. The patient’s suppressed heart rate increased after tumor removal, and the cardiac rhythm returned to normal postoperatively. Pathological examination demonstrated the diagnosis of schwannoma. Conclusions This case explains the link between the vagus nerve and the cardiovascular system, proving that a damaged cervical vagus nerve can inhibit the heart rate and lead to arrhythmias, and eventually requiring surgical intervention.

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Pre-operative embolization and excision of vagal schwannoma with rich vascular supply

Cited by 4 publications

References 20 publications

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

Diagnostic and Therapeutic Strategy for Vagal Schwannoma: Case Series and Literature Review

Quantification of vessel separation using the carotid-jugular angle to predict the nerve origin of neck peripheral nerve sheath tumours: a pooled analysis of cases from the literature and a single-center cohort

Cervical vagal nerve schwannoma induced arrhythmia: a rare case report and literature review

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