Pre-operative renal function predicts development of chronic renal insufficiency after orthotopic heart transplantation

Vossler, Mark; Ni, Hanyu; Toy, Warren; Hershberger, Ray E.

doi:10.1016/s1053-2498(02)00412-6

Cited by 68 publications

(45 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(27). Numerous retrospective studies have identified risk factors for the development of progressive chronic renal disease following pulmonary or cardiac transplantation (6,7,9,26,28,29 (34). It is also seen experimentally as a function of renal toxicity of a variety of agents (35,36).…”

Section: Granules In Intact Tubules (Upper Left) These Coalesce Intomentioning

confidence: 99%

Renal Histopathological Lesions After Lung Transplantation in Patients with Cystic Fibrosis

Lefaucheur

Nochy²,

Amrein³

et al. 2008

American Journal of Transplantation

View full text Add to dashboard Cite

We have analyzed the evolution of renal status beyond the perioperative period in patients with cystic fibrosis (CF) undergoing lung transplantation and presented histological analysis of 15 patients biopsied for an episode of accelerated renal function loss (RFL). The identification of specific etiologies of progressive kidney disease in patients with CF after lung transplantation should permit more effective post-transplant care of these patients. Episodes of accelerated RFL

show abstract

Section: Granules In Intact Tubules (Upper Left) These Coalesce Intomentioning

confidence: 99%

Renal Histopathological Lesions After Lung Transplantation in Patients with Cystic Fibrosis

Lefaucheur

Nochy²,

Amrein³

et al. 2008

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…Renal dysfunction is also a long-term consequence of OHT. This is most commonly attributed to the calcineurin inhibitors and may also result from TR (13,14,11,ISHLT registry data).…”

Section: Introductionmentioning

confidence: 99%

Donor Tricuspid Annuloplasty During Orthotopic Heart Transplantation: Long-Term Results of a Prospective Controlled Study

Jeevanandam

Russell

Mather

et al. 2006

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

“…Many studies have addressed this issue in heart transplant: the degree of renal insufficiency has been found to be associated with preoperative renal function [14], age of recipients, and GFR 1 year after transplantation [15]. Many authors have suggested that cyclosporine and early exposure to this drug causes renal deterioration in heart transplant children [3,5,16,17].…”

Section: Discussionmentioning

confidence: 99%

Long-term renal function in heart transplant children on cyclosporine treatment

et al. 2006

View full text Add to dashboard Cite

Renal function deterioration is a reason of concern in heart transplantation. Our aim was to evaluate long-term renal function in heart transplant children on cyclosporine (CsA) treatment and to investigate the effect of several variables possibly involved in renal function deterioration. Creatinine clearances were retrospectively reviewed in 50 children (median follow 99.7 months after heart transplant). Gender, age, and body weight at transplant, rejection episodes, CsA cumulative dose, and trough levels were analyzed. After an initial increase of the glomerular filtration rate (GFR), renal function worsened in most patients; 28% of the children developed renal insufficiency (defined as GFR <80 ml/min per 1.73 m2), which was already evident in the first 3 years. Neither CsA dose, trough levels, nor other patient characteristics were found to be associated with renal function deterioration. In this study renal failure occurred in one-third of the patients. The lack of association of CsA with renal insufficiency may be explained by several reasons, including the limitations of the retrospective design of the study. However, it is possible that the nephrotoxic effect of CsA is more likely to occur in a set of predisposed patients. These must be soon identified to evaluate early a calcineurin inhibitor-sparing strategy.

show abstract

Pre-operative renal function predicts development of chronic renal insufficiency after orthotopic heart transplantation

Cited by 68 publications

References 15 publications

Renal Histopathological Lesions After Lung Transplantation in Patients with Cystic Fibrosis

Renal Histopathological Lesions After Lung Transplantation in Patients with Cystic Fibrosis

Donor Tricuspid Annuloplasty During Orthotopic Heart Transplantation: Long-Term Results of a Prospective Controlled Study

Long-term renal function in heart transplant children on cyclosporine treatment

Contact Info

Product

Resources

About