2016
DOI: 10.1186/s12884-016-1002-0
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Pre-pregnancy obesity and non-adherence to multivitamin use: findings from the National Pregnancy Risk Assessment Monitoring System (2009–2011)

Abstract: BackgroundAlthough adequate folic acid or multivitamins can prevent up to 70 % of neural tube defects, the majority of U.S. non-pregnant women of childbearing age do not use multivitamins every day. Factors influencing consistent multivitamin use are not fully explored. This study aims to investigate the association between pre-pregnancy body mass index (BMI) and multivitamin use before pregnancy using a large, nationally representative sample of women with recent live births.MethodsThe national 2009–2011 Preg… Show more

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Cited by 18 publications
(17 citation statements)
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“…This level is still suboptimal and suggests a lack of awareness of the importance and risks related to folic-acid use, potentially due to limited health professional engagement or a preconception health check prior to their antenatal appointment. Interestingly, on adjustment for socio-demographic factors and pregnancy planning, overweight and obese women had a significantly lower odds of supplementing with folic-acid compared to normal-weight women, consistent with some [19,20] but not all [18] previous research. Irrespective, this remains of particular concern considering that preconception folic-acid supplementation is vital to reduce the risk of neural tube defects, for which overweight or obese women are at a higher risk [7,20].…”
Section: Discussionsupporting
confidence: 80%
See 1 more Smart Citation
“…This level is still suboptimal and suggests a lack of awareness of the importance and risks related to folic-acid use, potentially due to limited health professional engagement or a preconception health check prior to their antenatal appointment. Interestingly, on adjustment for socio-demographic factors and pregnancy planning, overweight and obese women had a significantly lower odds of supplementing with folic-acid compared to normal-weight women, consistent with some [19,20] but not all [18] previous research. Irrespective, this remains of particular concern considering that preconception folic-acid supplementation is vital to reduce the risk of neural tube defects, for which overweight or obese women are at a higher risk [7,20].…”
Section: Discussionsupporting
confidence: 80%
“…However, no relationship between BMI and overall preconception supplementation behavior was found [18]. This differs from previous reports showing reduced odds of folic-acid supplementation in obese women compared to those of a normal BMI [19,20]. Associations between pregnancy planning/intention (referred to herein as pregnancy planning) and BMI have also shown inconsistent findings, with some [21] but not all [22] studies reporting higher or lower odds of pregnancy planning with increasing BMI.…”
Section: Introductioncontrasting
confidence: 64%
“…However, folic acid deficiency is common in obesity, 57 and according to a recent national survey from the US, overweight and obese women are less likely to take multivitamins before pregnancy compared with normal weight women. 58 Thus it is possible that the increased risks of neural tube defects and congenital heart defects in offspring of obese mothers may be partly due to folic acid deficiency.…”
Section: Discussionmentioning
confidence: 99%
“…Pregnant obese women have lower plasma concentrations of methyl donors and this is correlated with levels found in the fetus (18). The explanation for these lower levels is unclear, but may include differences in bioavailability or metabolism of methyl donors in the context of higher adiposity (19) or decreased intake of recommended multivitamins (20). Lowered concentrations could be one mechanism by which aberrant DNA methylation is induced, which results in increased disease risk for offspring.…”
mentioning
confidence: 99%