Pre-pregnancy obesity compromises obstetric and neonatal outcomes

Hancke, Katharina; Gundelach, Theresa; Hay, Birgit; Sander, Sylvia G.; Reister, Frank; Weiß, Jürgen

doi:10.1515/jpm-2014-0069

Cited by 12 publications

(8 citation statements)

References 6 publications

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“…Overweight and even more so obesity are major pre-disposing factors for the development of diabetes throughout pregnancy 45 , 46 . Our cohort used for HDL isolation could not be matched for maternal BMI; mothers in the GDM group had significantly higher BMI, both before pregnancy and at time of delivery.…”

Section: Discussionmentioning

confidence: 99%

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress

Schliefsteiner

Hirschmugl

Kopp

et al. 2017

Sci Rep

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Increased Lipoprotein associated phospholipase A2 (LpPLA2) has been associated with inflammatory pathologies, including Type 2 Diabetes. Studies on LpPLA2 and Gestational Diabetes Mellitus (GDM) are rare, and have focused mostly on maternal outcome. In the present study, we investigated whether LpPLA2 activity on foetal lipoproteins is altered by maternal GDM and/or obesity (a major risk factor for GDM), thereby contributing to changes in lipoprotein functionality. We identified HDL as the major carrier of LpPLA2 activity in the foetus, which is in contrast to adults. We observed marked expression of LpPLA2 in placental macrophages (Hofbauer cells; HBCs) and found that LpPLA2 activity in these cells was increased by insulin, leptin, and pro-inflammatory cytokines. These regulators were also increased in plasma of children born from GDM pregnancies. Our results suggest that insulin, leptin, and pro-inflammatory cytokines are positive regulators of LpPLA2 activity in the foeto-placental unit. Of particular interest, functional assays using a specific LpPLA2 inhibitor suggest that high-density lipoprotein (HDL)-associated LpPLA2 exerts anti-oxidative, athero-protective functions on placental endothelium and foetus. Our results therefore raise the possibility that foetal HDL-associated LpPLA2 might act as an anti-inflammatory enzyme improving vascular barrier function.

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Section: Discussionmentioning

confidence: 99%

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress

Schliefsteiner

Hirschmugl

Kopp

et al. 2017

Sci Rep

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“…Our results demonstrated that non‐White women were 3 times more likely to develop GDM. Obesity and high BMI have been consistently shown to be associated with an increased risk of GDM (Athukorala, Rumbold, Willson, & Crowther, ; Crane, White, Murphy, Burrage, & Hutchens, ; Hancke et al., ). Likewise in this study, women experienced a 6% increased risk of GDM for every BMI unit increase.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Psychosocial Predictors of Gestational Diabetes and Birth Weight

Wilson

Dyer²,

Latendresse

et al. 2015

Journal of Obstetric, Gynecologic & Neonatal Nursing

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“…Data from prospective cohort studies showed that normal weight women had a higher significant risk of gaining less weight than what was recommended. 5 Women with lower gestational weight gain had an increased risk for preterm birth, low birth weight, small for gestational age babies and a decreased risk for caesarean birth. 6 A population-based study was done in the United States of America involving 124,348 pregnant women to assess their GWG.…”

Section: How To Cite This Articlementioning

confidence: 99%

“…8 12.5 -18.0 19.8 -26.0 11.5 -16.0 26.1 -29.0 7.0 -11.5 > 29 7 Table 1 As per the BMI categories proposed by WHO, the advised weight gain was as follows 4 Pre-pregnancy BMI Recommended Weight Gain in kgs < 18. 5 12.5 -18.0 18.5 -24. 9 11.5 -16.0 25.0 -29.…”

Section: How To Cite This Articlementioning

confidence: 99%

The Prevalence of Abnormal Body Mass Index (Bmi) and Comparison of the Who General and Asian Standard Bmi Classification Among First Trimester South Indian Women

Rachel¹,

Rajadoss²,

Ravichandran³

2018

jebmh

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BACKGROUND Nutrition plays an important role in a woman's ability to sustain her pregnancy. Nearly 54% of Asian pregnant women were found to be at increased risk of inadequate energy intake. During pregnancy, a woman requires an extra 300-400 kcal/day, restriction of which leads to adverse maternal and foetal outcomes. Less is known about the impact of gestational weight gain in conjunction with BMI on perinatal outcomes in healthy pregnant women without other co-morbidities. The objectives of the study were to assess the prevalence of abnormal BMI in early pregnancy and to compare the two standards of BMI classification namely, the WHO classification for the general population and the revised classification for Asian Population. MATERIALS AND METHODS This study was a prospective descriptive study. The study was done during the months of August and September 2016 in a tertiary care hospital in South India. All pregnant women who registered in the hospital for antenatal care, prior to 12 weeks and 6 days were recruited. The profiles of the enrolled pregnant women were collected using a proforma and the values of BMI for each class from the WHO general classification system was compared to the corresponding class of the WHO classification system for the Asian population. The sample size needed for this study was estimated to be 384, assuming a prevalence of 50%, absolute precision of 5% and 95% confidence interval.

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Pre-pregnancy obesity compromises obstetric and neonatal outcomes

Abstract: Pre-pregnancy obesity is associated with higher incidences of gestational diabetes and preeclampsia. Our study shows that obese women have a higher risk of non-elective cesarean section and preterm birth.

Cited by 12 publications

References 6 publications

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress

Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress

Exploring the Psychosocial Predictors of Gestational Diabetes and Birth Weight

The Prevalence of Abnormal Body Mass Index (Bmi) and Comparison of the Who General and Asian Standard Bmi Classification Among First Trimester South Indian Women

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