Pre-pregnancy obesity, gestational diabetes or gestational weight gain: Which is the strongest predictor of pregnancy outcomes?

Bianchi, Cristina; Gennaro, Giovanni; Romano, Matilde; Aragona, Michele; Battini, Lorella; Prato, Stefano Del; Bertolotto, Alessandra

doi:10.1016/j.diabres.2018.08.019

Cited by 44 publications

(33 citation statements)

References 37 publications

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“…According to the current state of scientific knowledge, pre-pregnancy obesity and excessive gestational weight gain (EGWG) as well as gestational diabetes mellitus (GDM) have been regarded as independent risk factors for post-partum complications in both mothers and their children, which will subsequently lead to an increased risk of chronic diseases later in their lives [1,2,3,4,5]. It has been observed that women with a previous history of GDM and EGWG are much more prone to suffer from type 2 diabetes mellitus (T2DM), obesity, cardiovascular diseases (CVDs), and metabolic syndrome in the future [1,2,3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid-Binding Protein 4—An “Inauspicious” Adipokine—In Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain and Gestational Diabetes Mellitus

Kimber-Trojnar

Patro-Małysza

Trojnar

et al. 2018

JCM

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The exact roles of adipokines in the pathogenesis of type 2 diabetes and obesity are still unclear. The aim of the study was to evaluate fatty acid binding protein 4 (FABP4) concentrations in the serum and urine of women with excessive gestational weight gain (EGWG) and gestational diabetes mellitus (GDM) in the early post-partum period, with reference to their laboratory test results, body composition, and hydration status. The study subjects were divided into three groups: 24 healthy controls, 24 mothers with EGWG, and 22 GDM patients. Maternal body composition and hydration status were evaluated by the bioelectrical impedance analysis (BIA) method. Concentrations of FABP4, leptin, and ghrelin were determined via enzyme-linked immunosorbent assay (ELISA). Healthy women were characterized by the lowest serum leptin concentrations and by a negative correlation between the serum and urine FABP4 levels. Serum FABP4 levels were the highest in the GDM group. Serum FABP4 and leptin concentrations correlated positively in the GDM group. The EGWG group had the highest degree of BIA disturbances in the early puerperium and positive correlations between the urine FABP4 and serum leptin and ghrelin concentrations. The physiological and pathological significance of these findings requires further elucidation.

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Section: Introductionmentioning

confidence: 99%

Fatty Acid-Binding Protein 4—An “Inauspicious” Adipokine—In Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain and Gestational Diabetes Mellitus

Kimber-Trojnar

Patro-Małysza

Trojnar

et al. 2018

JCM

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“…9 The prevalence of newborn macrosomia among women with uncontrolled glucose level is 6.1%, similar to other study, yet there no association between glucose control in pregnancy. 10 In contrast to a general thought of a significant association between glucose control and macrosomia newborn. 11 Moreover, study showed that pregestational diabetic mellitus patients is significantly associated to small birth weight and appropriate birthweight newborn.…”

Section: Discussionmentioning

confidence: 90%

Macrosomic Newborn and Glucose Level in Lean Pregnant Diabetes Mellitus Patients at Dr. Soetomo General Hospital Surabaya

Venugopal

Joewono²,

Lestari³

2018

amj

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“…30.0 kg/m2, is increasing over time. 5,12,18 Pregestational BMI is a risk factor for the development of maternal and perinatal complications. 24,27 In the clinical practice, obesity and gestational diabetes commonly coexist and it is controversial which one the two conditions (gestational diabetes or maternal obesity) is more strongly associated with risk for adverse maternal and neonatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Preeclampsia, Advanced Maternal Age and Maternal Obesity in Neonatal Outcomes Among Women with Gestational Diabetes

Nunes

Ladeiras

Machado

et al. 2020

Rev Bras Ginecol Obstet

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Objective The present study aims to analyze adverse fetal or neonatal outcomes in women with gestational diabetes, including fetal death, preterm deliveries, birthweight, neonatal morbidity and mortality, as well as the synergic effect of concomitant pregnancy risk factors and poor obstetric outcomes, as advanced maternal age, maternal obesity and pre-eclampsia in their worsening. Methods The present cohort retrospective study included all pregnant women with gestational diabetes, with surveillance and childbirth at the Hospital da Senhora da Oliveira during the years of 2017 and 2018. The data were collected from the medical electronic records registered in health informatic programs Sclinico and Obscare, and statistical simple and multivariate analysis was done using IBM SPSS Statistics. Results The study participants included 301 pregnant women that contributed to 7.36% of the total institution childbirths of the same years, in a total of 300 live births. It was analyzed the influence of pre-eclampsia coexistence in neonatal morbidity (p = 0.004), in the occurrence of newborns of low and very low birthweight (p < 0.01) and in preterm deliveries (p < 0.01). The influence of maternal obesity (p = 0.270; p = 0.992; p = 0.684) and of advanced maternal age in these 3 outcomes was also analyzed (p = 0,806; p = 0.879; p = 0.985).Using a multivariate analysis, the only models with statistic significance to predict the three neonatal outcomes included only pre-eclampsia (p = 0.04; p < 0.01; p < 0.01). Conclusion Only coexistence of pre-eclampsia showed an association with adverse neonatal outcomes (neonatal morbidity, newborns of low and very low birthweight and preterm deliveries) and can be used as a predictor of them in women with gestational diabetes.

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Pre-pregnancy obesity, gestational diabetes or gestational weight gain: Which is the strongest predictor of pregnancy outcomes?

Cited by 44 publications

References 37 publications

Fatty Acid-Binding Protein 4—An “Inauspicious” Adipokine—In Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain and Gestational Diabetes Mellitus

Fatty Acid-Binding Protein 4—An “Inauspicious” Adipokine—In Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain and Gestational Diabetes Mellitus

Macrosomic Newborn and Glucose Level in Lean Pregnant Diabetes Mellitus Patients at Dr. Soetomo General Hospital Surabaya

The Influence of Preeclampsia, Advanced Maternal Age and Maternal Obesity in Neonatal Outcomes Among Women with Gestational Diabetes

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