Little is known about the impact of "home-based records'' on the health promotion of mothers and children. Considering this, we compiled and analysed existing evidence on the effectiveness of a specific home-based record, the Maternal and Child Health Handbook (MCHHB), in enhancing the health of mothers and their children. A systematic search of PubMed, Google Scholar, Maternity, and Infant Care, CINHAL, and Ovid was conducted. All types of original research articles published in English were considered. A narrative synthesis was used due to the heterogeneity of findings among the included studies. Out of a total of 1351 papers, 45 studies were included. Breastfeeding, immunisation, family planning, antenatal care, maternal nutrition, maternal Tetanus Toxoid (TT) immunisation, vitamin A and iron supplements, smoking and alcohol consumption during pregnancy, healthy and safe delivery, awareness of pregnancy complications, and healthy child development are all areas where MCHHB has been implemented and evaluated. Although one study found no effect, our findings indicate a positive impact. The results emphasised the effectiveness and value of MCHHB in enhancing maternal and infant health. However, given that only a small number of studies were available for each outcome group, we suggest more research be conducted on the MCHHB's positive effects on mothers’ and children’s health.