Pre-schoolers suffering from psychiatric disorders show increased cortisol secretion and poor sleep compared to healthy controls

Hatzinger, Martin; Brand, Serge; Perren, Sonja; Wyl, A von; Stadelmann, Stephanie; Klitzing, Kai von; Holsboer‐Trachsler, Edith

doi:10.1016/j.jpsychires.2012.01.018

Cited by 31 publications

(21 citation statements)

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“…Other studies have reported similar findings (i.e., higher cortisol related to more impulsivity) for boys but not girls (e.g., Dettling, Gunnar, & Dozella, 1999). Although these studies accentuate the potential complexity of the relations between cortisol and impulsivity that future work needs to routinely consider, other studies have reported direct relations between elevated cortisol and more impulsivity (e.g., Almedia, Lee, & Coccaro, 2010; Bruce, Davis, & Gunnar, 2002; Hatzinger et al, 2012). …”

Section: Self-regulation Intergenerational Transmission Modelmentioning

confidence: 96%

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

Bridgett¹,

Burt²,

Edwards³

et al. 2015

Psychological Bulletin

507

476

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This review examines mechanisms contributing to the intergenerational transmission of self-regulation. To provide an integrated account of how self-regulation is transmitted across generations, we draw from over 75 years of accumulated evidence, spanning case studies to experimental approaches, in literatures covering developmental, social, and clinical psychology, and criminology, physiology, genetics, and human and animal neuroscience (among others). First, we present a taxonomy of what self-regulation is and then examine how it develops – overviews that guide the main foci of the review. Next, studies supporting an association between parent and child self-regulation are reviewed. Subsequently, literature that considers potential social mechanisms of transmission, specifically parenting behavior, inter-parental (i.e., marital) relationship behaviors, and broader rearing influences (e.g., household chaos) are considered. Finally, literature providing evidence that prenatal programming may be the starting point of the intergenerational transmission of self-regulation is covered, along with key findings from the behavioral and molecular genetics literatures. To integrate these literatures, we introduce the Self-Regulation Intergenerational Transmission Model, a framework that brings together prenatal, social, and neurobiological mechanisms (spanning endocrine, neural, and genetic levels, including gene-environment interplay and epigenetic processes) to explain the intergenerational transmission of self-regulation. This model also incorporates potential transactional processes between generations (e.g., children’s self-regulation and parent-child interaction dynamics that may affect parents’ self-regulation) that further influence intergenerational processes. In pointing the way forward, we note key future directions and ways to address limitations in existing work throughout the review and in closing. We also conclude by noting several implications for intervention work.

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Section: Self-regulation Intergenerational Transmission Modelmentioning

confidence: 96%

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

Bridgett¹,

Burt²,

Edwards³

et al. 2015

Psychological Bulletin

507

476

View full text Add to dashboard Cite

show abstract

“…In this regard, an insufficient decline or variations of the normal REM sleep decline during development is proposed to underpin a broad spectrum of child and adolescent psychiatric disorders (Partonen, 1998; Kobayashi et al, 2004; Garcia-Rill et al, 2008; Brand and Kirov, 2011; Kirov and Brand, 2014). Given that both the hypothalamus-pituitary-adrenocortical axis activation and REM sleep overdrive are closely associated in psychiatric conditions (Steiger et al, 2013), this notion has received an indirect support by documenting an existence of elevated cortisol levels in association with disturbed sleep and impaired neurobehavioral functions in a cohort of children with various psychiatric symptoms (Hatzinger et al, 2012), and thus, probably, with deviant stress sensitivity (Brand and Kirov, 2011; Gruber, 2014). However, whether and how REM sleep in common developmental child psychiatric disorders may be linked to neurobehavioral functioning is still less well understood.…”

Section: Introductionmentioning

confidence: 99%

Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children

et al. 2017

Self Cite

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Rapid eye movement (REM) sleep has been shown to be related to many adaptive cognitive and behavioral functions. However, its precise functions are still elusive, particularly in developmental psychiatric disorders. The present study aims at investigating associations between polysomnographic (PSG) REM sleep measurements and neurobehavioral functions in children with common developmental psychiatric conditions compared to typically developing children (TDC). Twenty-four children with attention-deficit/hyperactivity disorder (ADHD), 21 with Tourette syndrome/tic disorder (TD), 21 with ADHD/TD comorbidity, and 22 TDC, matched for age and gender, underwent a two-night PSG, and their psychopathological scores and intelligence quotient (IQ) were assessed. Major PSG findings showed more REM sleep and shorter REM latency in the children with psychiatric disorders than in the TDC. Multiple regression analyses revealed that in groups with developmental psychopathology, REM sleep proportion correlated positively with scores of inattention and negatively with performance IQ. In contrast, in the group of TDC, REM sleep proportion correlated negatively with scores of inattention and positively with performance IQ. Whilst shorter REM latency was associated with greater inattention scores in children with psychopathology, no such an association existed in the group of TDC. Altogether, these results indicate an opposite impact of REM sleep on neurobehavioral functioning, related to presence or absence of developmental psychiatric disorders. Our findings suggest that during development, REM sleep functions may interact dissimilarly with different pathways of brain maturation.

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“…Greater youth-report sleep fragmentations are associated with higher total cortisol level in children (El-Sheikh et al, 2008). Shorter sleep duration, longer sleep onset latency, lower sleep efficiency, and greater sleep fragmentation based on actigraphyassessment are associated with higher afternoon and evening cortisol levels, higher total cortisol, and flatter diurnal slopes in children (El-Sheikh et al, 2008;Hatzinger et al, 2012;Pesonen et al, 2012;Räikkönen et al, 2010). As well, adolescent boys, but not girls, with shorter actigraphy-derived sleep duration have higher morning cortisol levels and a lower cortisol awakening response (Pesonen et al, 2014).…”

Section: Cihr Author Manuscriptmentioning

confidence: 97%

Poor sleep as a pathophysiological pathway underlying the association between stressful experiences and the diurnal cortisol profile among children and adolescents

McGrath

Gouin

2015

Psychoneuroendocrinology

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SummaryRecent evidence suggests that poor sleep is a potential pathway underlying the association between stressful experiences and the diurnal cortisol profile. However, existing findings are largely limited to adults. The present study examines whether poor sleep (duration, quality) mediates the relation between stressful experiences and the diurnal cortisol profile in children and adolescents. Children and adolescents (N = 220, M age = 12.62) provided six saliva samples over two days to derive cortisol indices (bedtime, AUC AG , AUC TG , slope MAX ). Perceived stress, stressful life events, self-reported sleep duration, and sleep quality were measured. Using bootstrapping analyses, sleep quality mediated the relation between perceived stress and AUC TG (R2 = 0.10, F(7, 212) = 3.55, p = .001; 95% BCI[0.09, 1.15]), as well as the relation between stressful life events and AUC TG (R2 = 0.11, F(7, 212) = 3.69, p = .001; 95% BCI[0.40, 3.82]).These mediation models remained significant after adjusting for sleep duration, suggesting that poor sleep quality underlies the association between stressful experiences and the diurnal cortisol profile in children and adolescents. Longitudinal data combined with objectively-measured sleep is essential to further disentangle the complex association between sleep and stress. KeywordsSleep; Cortisol; Stressful life events; Perceived stress; Child; Adolescent Stress is known to alter cortisol secretion. Exposure to acute laboratory-induced stressors elicits transient increases in cortisol level (Dickerson and Kemeny, 2004). Naturally occurring stressful experiences, including perceived stress and stressful life events, have also been associated with a disrupted diurnal cortisol profile. Adults who report greater perceived stress (i.e., nonspecific, subjective appraised stress, Cohen et al., 1995) CIHR Author ManuscriptCIHR Author Manuscript CIHR Author Manuscript awakening response, total cortisol level, and flatter diurnal slopes (Miller et al., 2007;Pruessner et al., 1999;Schulz et al., 1998). Greater stressful life events (e.g., unemployment, divorce) are associated with higher morning and evening cortisol levels and flatter diurnal slopes (Miller et al., 2007). Similar findings have been established in both children and adolescents (hereafter referred to as "youth" for parsimony). Youth who report greater stressful life events (e.g., family conflict, academic stress) have a higher cortisol awakening response and elevated afternoon cortisol levels than their less stressed counterparts (Gustafsson et al., 2010;Wolf et al., 2008). While there is convincing evidence that stressful experiences disrupt the diurnal cortisol profile, the potential pathways underlying this association remain unclear.Sleep is one plausible pathway by which stressful experiences disrupt the diurnal cortisol profile. The sleep-wake cycle has a close, temporal association with diurnal cortisol secretion. Nocturnal sleep onset reliably exerts an inhibitory effect on cortisol secretion (Van Cauter et al.,...

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Pre-schoolers suffering from psychiatric disorders show increased cortisol secretion and poor sleep compared to healthy controls

Cited by 31 publications

References 83 publications

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children

Poor sleep as a pathophysiological pathway underlying the association between stressful experiences and the diurnal cortisol profile among children and adolescents

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