Pre-surgical cortical activation to food pictures is associated with weight loss following bariatric surgery

Ness, Abigail; Bruce, Jared M.; Bruce, Amanda S.; Aupperle, Robin L.; Lepping, Rebecca J.; Martin, Laura E.; Hancock, Laura M.; Patrician, Trisha M.; Malley, Steve; Selim, Niazy; Savage, Cary R.

doi:10.1016/j.soard.2014.06.005

Cited by 21 publications

(22 citation statements)

References 34 publications

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“…The observed changes in neural processing after RYGB support an improved response inhibition towards high-energy foods. Moreover, research on the effect of laparoscopic adjustable gastric banding, showed increased activity in similar frontal regions such as medial, middle, superior frontal gyrus, that was associated with weight loss (Ness et al, 2014). Together this highlights the role of neural circuitry implicated in reward and cognitive control in the success and maintenance of weight loss surgery.…”

Section: Discussionmentioning

confidence: 83%

Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass

Zoon

Bruijn

Jager

et al. 2018

Biological Psychology

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Neural changes indicate improved response inhibition towards high-energy food cues, altered influence of metabolic control during response inhibition towards low-energy food cues and a more positive attitude to both high-energy and low-energy food after RYGB. Alterations in neural circuits involved in inhibitory control, satiety signalling and reward processing may contribute to effective weight-loss after RYGB.

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Section: Discussionmentioning

confidence: 83%

Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass

Zoon

Bruijn

Jager

et al. 2018

Biological Psychology

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“…Longitudinal studies using task‐based functional magnetic resonance imaging (fMRI) have demonstrated changes in activity following bariatric surgery, predominantly reductions in response to palatable food images in food motivation and reward circuitry, suggesting normalization in brain activity . Baseline food‐cue reactivity in the hypothalamus, reward circuitry (including nucleus accumbens [NAcc]), and frontal regions have been shown to be negatively correlated with food reward sensitivity and weight loss at 1 to 12 months following bariatric surgery procedures, including sleeve gastrectomy (SG) , suggesting task‐based fMRI metrics could provide value in predicting outcomes; however, other studies have not found relationships between baseline neuroimaging metrics and postsurgical weight loss . While task‐based fMRI is helpful in investigating how brain regions respond to certain stimuli, resting‐state fMRI (rsfMRI) allows insight into intrinsic brain network connectivity during rest, and this type of imaging has been shown to confer unique predictive abilities for disease course and treatment outcomes in psychiatric conditions.…”

Section: Introductionmentioning

confidence: 99%

Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

Cerit

Davidson

Hye

et al. 2019

Obesity

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Objective The effects of sleeve gastrectomy (SG) on functional connectivity (FC) and associations with weight loss and eating‐related cognitive control were investigated. Methods In a longitudinal study, 14 SG patients (13 female; 42.1 presurgery BMI) completed study visits 1 month pre surgery and 12 months post surgery. Patients completed the Dutch Eating Behavior Questionnaire and resting‐state functional magnetic resonance imaging scanning to measure FC. Data were analyzed using a seed‐to‐voxel approach in the CONN Toolbox to investigate pre‐/postsurgery changes (n = 12) and to conduct predictive analysis (n = 14). Results Seed‐to‐voxel analysis revealed changes in magnitude (decreases) and directionality (positively correlated to anticorrelated) of FC pre to post surgery within and between default mode network, salience network, and frontoparietal network nodes [Family‐Wise Error (FWE) corrected at P < 0.05]. Baseline FC of the nucleus accumbens (with insula) and hypothalamus (with precentral gyrus) predicted 12‐month post‐SG % total weight loss (FWE‐P < 0.05). Baseline FC of the hippocampus, frontoparietal network, and default mode network nodes predicted improvement in cognitive control of eating behavior 12 months after SG (FWE‐P < 0.05). Conclusions Our findings demonstrate changes in FC magnitude and directionality post versus pre surgery within and between resting‐state networks and frontal, paralimbic, and visual areas in SG patients. Baseline FC predicted weight loss and changes in cognitive control of food intake behavior at 12 months. These could serve as predictive biomarkers for bariatric surgery.

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“…One study specifically focused on the executive control network activity and was performed on patients after bariatric surgery and did not include any baseline presurgery data 13 . The other study tested BMI loss at six months follow-up against presurgery cerebral activity during the viewing of food versus non food pictures, showing that the activity in areas involved in cognitive control was related to low BMI maintenance 14 .…”

Section: Introductionmentioning

confidence: 99%

Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study

Olivo

Zhou

Sundbom

et al. 2017

Sci Rep

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Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before, one month after and one year after Roux-en-Y gastric bypass surgery (RYGB). 12 lean controls were also enrolled. Resting-state fMRI was acquired for all participants following an overnight fast and after a 260 kcal load. Connectivity between regions involved in food-related saliency attribution and reward-driven eating behavior was stronger in presurgery patients compared to controls, but progressively weakened after follow-up. At one year, changes in networks related to cognitive control over eating and bodily perception also occurred. Connectivity between regions involved in emotional control and social cognition had a temporary reduction early after treatment but had increased again after one year of follow-up. Furthermore, we could predict the BMI loss by presurgery connectivity in areas linked to emotional control and social interaction. RYGBP seems to reshape brain functional connectivity, early affecting cognitive control over eating, and these changes could be an important part of the therapeutic effect of bariatric surgery.

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Pre-surgical cortical activation to food pictures is associated with weight loss following bariatric surgery

Cited by 21 publications

References 34 publications

Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass

Altered neural inhibition responses to food cues after Roux-en-Y Gastric Bypass

Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study

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