Pre-symptomatic Ulcerative Colitis

Ormerod, T P; Tonkin, Richard

doi:10.1177/003591576305600421

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“…In the present study anaemia did not parallel either the duration or severity of the acute exacerbation leading to admission; however, various additional factors may occur to modify the degree of anaemia, such as previous iron therapy and the amount of iron stores existing before the acute attack. The onset of symptoms may occasionally be a poor guide to the start of the disease process; a case has been reported (Ormerod and Tonkin, 1963) where histological changes preceded symptoms altogether. Also diarrhoea, although usually an early symptom, may be inconspicuous if minimal rectal changes have occurred even with advanced colonic disease.…”

Section: Group a Patientsmentioning

confidence: 99%

Observations on the incidence and cause of anaemia in ulcerative colitis.

Ormerod¹

1967

Gut

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EDITORIAL COMMENT These studies confirm the view that there is an iron-deficiency state in ulcerative colitis and that this overshadows the influence of infection as a factor causing anaemia.The frequency of anaemia has been well established in the many reported series of patients with ulcerative colitis yet the aetiology of the anaemia is still not fully known. The purpose of this study is first to discover whether low haemoglobin levels are associated with any special features in the case reports of 479 patients (group A) and secondly to investigate an additional 28 ward patients (group B) to ascertain the parts played by iron deficiency, shortening of the red cell life, and lack of vitamin B12 or folic acid. METHODS

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Section: Group a Patientsmentioning

confidence: 99%