“…For the important outcome of cognitive knowledge, we identified 4 RCTs: 2 were of very low quality (downgraded for serious risk of bias, imprecision, and possible publication bias), 53,54 1 was of low quality (downgraded for risk of bias and imprecision), 57 and 1 was of moderate quality (downgraded for imprecision). 55 These studies differed in the teaching methods used to compare cognitive outcome, including simulation (traditional course format), multimedia (computer-based learning), self-directed reading, limited instruction (larger student-to-instructor ratio), and self-directed computer-based learning.…”