Pre-transplant biomarkers and prediction of post-transplant outcomes in kidney transplantation

Abstract

New findings in "omics" and genomics allowed us to find out new robust biomarkers that may allow a diagnosis avoiding invasive and dangerous procedures. This could be of particular importance if applied on transplant clinical practice. In kidney transplantation several pre-transplant biomarkers revealed useful either for a better renal allocation and as predictive of future outcomes as delayed graft function, rejections and long term outcome. Different biomarkers have been recently described bringing interesting results regarding predictive outcomes in the field of kidney transplantation. In this setting, an evaluation for pre-transplant biomarkers especially in the era of expanded criteria donors (ECDs) and non-heart-beating donors (NHBDs) could help transplant physicians to make decisions on allocation or even on discharge of the allograft. Furthermore, identify pre-transplant biomarkers is useful for a risk stratification of delayed graft function (DGF), acute rejection (AR) episodes and chronic allograft dysfunction (CAD) after kidney transplantation (KT). In this review, we report recent findings on pre-transplant biomarkers from various biological samples from donors or recipients. Please cite this paper as:

Il trapianto renale da cadavere: valutazione di idoneità del donatore e del rene

“…24 In aggiunta, è possibile effettuare sul liquido refluo analisi seriate per determinare le concentrazioni di biomarcatori di danno renale, anche se questi ultimi non hanno un valore predittivo assoluto, come è stato evidenziato in una nostra recente review. 25…”