Pre-transplant Mechanical Ventilation Increases Short-term Morbidity and Mortality in Pediatric Patients With Cystic Fibrosis

Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation

“…1 For some patients awaiting lung transplantation, disease progression leads to deterioration and respiratory failure necessitating life support, which is associated with worse post-transplant outcomes. [2][3][4] For individuals who require mechanical ventilation before lung transplantation, the 1-y survival rate is 57-62% in comparison with 75-80% for those who are not supported with invasive ventilation at the time of transplant. [2][3][4] Initial studies of subjects who required extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation demonstrated even lower survival rates.…”

“…[2][3][4] For individuals who require mechanical ventilation before lung transplantation, the 1-y survival rate is 57-62% in comparison with 75-80% for those who are not supported with invasive ventilation at the time of transplant. [2][3][4] Initial studies of subjects who required extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation demonstrated even lower survival rates. [4][5][6] These survival trends are likely representative of historically late initiation of ECMO for those patients in need of lung transplantation.…”

Novosti v Obravnavi Pljučne Bolezni Pri Otrocih in Mladostnikih S Cistično Fibrozo

“…Stanje se nekoliko izboljšuje šele po izboljšavi metod zunajtelesne oksigenacije. 56 Tako kot predpriprava je tudi vodenje bolnikov po presaditvi zaradi značilnosti bolezni specifično.47-49 Poleg standardne obravnave, ki je enaka kot pri ostalih bolnikih po presaditvi pljuč, je pomembno dobro vodenje ostalih, za CF specifičnih stanj, ki ostanejo tudi po presaditvi pljuč. Od skrbnega nadzora nad ustrezno, za CF značilno prehrano, do zdravljenja okužb, pri katerih so pogosto povzročitelji vsaj v začetku enaki kot so bili pred presaditvijo pljuč, osteoporoze, sladkorne bolezni in specifičnih zapletov, kot je na primer sindrom distalne obstrukcije tankega črevesja.…”

Long-Term Mechanical Ventilation: Management Strategies

“…The selection and preparation of a patient for lung transplant from PMV is both complex and rigorous, as outcomes for these patients can be worse compared with non-ventilated patients undergoing lung transplantation. 28 Respiratory failure and PMV can occur as a complication of pulmonary hypertension (usually primary). The advances in treatment of pulmonary hypertension have resulted in improved survival in this population, 29 and in some cases allowed successful weaning from PMV.…”