Pre-transplant Quality of Life Does Not Predict Survival After Lung Transplantation

Vermeulen, Karin M.; TenVergert, Elisabeth M.; Verschuuren, Erik; Erasmus, Michiel E.; Bij, Wim van der

doi:10.1016/j.healun.2008.03.011

Cited by 25 publications

(21 citation statements)

References 28 publications

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“…5 In addition, studies examining pretransplant quality of life have not found a relationship between poorer function and increasing rates of mortality. 30 Surprisingly, in the present study, we did not fi nd a relationship between preoperative depression, anxiety, and elevated rates of mortality following transplantation. Our fi nding that persistent depressive symptoms were predictive of subsequent survival is potentially important and warrants further investigation, particularly because baseline levels of depression were not predictive of survival.…”

Section: Pretransplant Neurocognitive Function and Mortalitycontrasting

confidence: 82%

Neurobehavioral Functioning and Survival Following Lung Transplantation

Smith

Blumenthal

Carney

et al. 2014

Chest

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Background: Neurobehavioral functioning is widely recognized as being an important consideration in lung transplant candidates, but little is known about whether these factors are related to clinical outcomes. The present study examined the relationship of neurobehavioral functioning, including measures of executive function and memory, depression, and anxiety, to long-term survival among lung transplant recipients.

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Section: Pretransplant Neurocognitive Function and Mortalitycontrasting

confidence: 82%

Neurobehavioral Functioning and Survival Following Lung Transplantation

Smith

Blumenthal

Carney

et al. 2014

Chest

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“…Furthermore, among patients enrolled in our study, we found a mortality rate of 18 per 100 person-years after LT, which is in line with data reported from international registries. Just as found by Vermeulen et al [27], in our sample, pretransplant HRQoL did not predict survival after LT, although mortality tended to be slightly higher among patients with lower HRQoL at the pre-LT assessment. Factors such as age, sex, type of LT, FEV1% predicted, 6MWT distance, and GHQ score at pre-transplant assessment did not influence the relation between pre-LT HRQoL and survival.…”

Section: Discussionsupporting

confidence: 79%

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Ricotti

Martinelli

Caspani

et al. 2017

Monaldi Arch Chest Dis

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Lung transplantation (LT) increases the life expectancy of patients affected by end stage pulmonary disease; specifically, its ultimate aims are to improve survival and health related quality of life (HRQoL). The aim of the present longitudinal study was to determine the HRQoL trajectory and changes in functional capacity from time of entry in the waiting list for LT to 2 year after LT. The study included sixty-nine outpatients enrolled in a single medical center when they entered the waiting list for LT and who subsequently received it. They were then followed up over 2 years after LT. HRQoL was assessed by the physical and mental component summary (PCS and MCS) scores of the 36-item Short Form Health Survey (SF-36) and Saint George's Respiratory Questionnaire (SGRQ). Psychological distress was evaluated with the General Health Questionnaire (GHQ), and functional capacity was investigated using the six-minute walk test (6MWT) and forced expiratory volume (FEV1). Patients showed low SF-36 PCS (30.5±7.8) and SGRQ total (61.8±17.5) scores at entry in the waiting list, but exhibited significant changes over time after LT (p<0.001). Furthermore, patients who showed an increase of at least 50% in SF36 PCS and SGRQ scores at 6 months survived longer. Both FEV1 and 6MWT distance as well as GHQ scores significantly changed over time, with improvements occurring in the first 6 months after LT but no major changes thereafter. Out of the 69 patients enrolled, 32 died over a median follow-up of 51 months. Although mortality tended to be slightly higher for patients with lower HRQoL at the baseline assessment, this difference was not statistically significant. HRQoL evaluations appear critical in the follow-up of LT candidates, in particularly SGRQ, because of its specificity in targeting respiratory symptoms and functional wellbeing.

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“…Among lung recipients, studies that have examined depression and anxiety symptoms have not found any links to posttransplant mortality [12 ▪ ,13–15]. To date, no studies have been conducted to examine whether actual psychiatric diagnoses are linked to increased mortality risk.…”

Section: Depression and Anxiety As Predictors Of Mortality And Morbiditymentioning

confidence: 99%

Psychiatric disorders as risk factors for adverse medical outcomes after solid organ transplantation

Rosenberger

Dew²,

Crone³

et al. 2012

Current Opinion in Organ Transplantation

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Purpose of review Given that the prevalence of psychiatric disorders in transplant candidates and recipients is substantially higher than in the general population, and that linkages between psychiatric disorders and medical outcomes for nontransplant-related diseases have been established, it is important to determine whether psychiatric disorders predict posttransplant medical outcomes. Recent findings Most research has focused on the association between depression (both pretransplant and posttransplant) and posttransplant mortality. Some research has examined transplant-related morbidity outcomes, such as graft rejection, posttransplant malignancies, and infection. However, methodological limitations make it difficult to compare existing studies in this literature directly. Overall, the studies presented in this review indicate that psychiatric distress occurring in the early transplant aftermath bears a stronger relationship to morbidity and mortality outcomes than psychiatric distress occurring before transplant. Summary The literature on the impact of psychiatric conditions on the morbidity and mortality of solid organ transplant recipients remains inconclusive. More research is needed in order to investigate these associations among a broader range of psychiatric predictors, morbidity outcomes, and recipient populations. Until evidence suggests otherwise, we recommend frequent monitoring of psychiatric symptoms during the first year after transplantation to aid in early identification and treatment during this critical period of adjustment.

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Pre-transplant Quality of Life Does Not Predict Survival After Lung Transplantation

Cited by 25 publications

References 28 publications

Neurobehavioral Functioning and Survival Following Lung Transplantation

Neurobehavioral Functioning and Survival Following Lung Transplantation

Changes in quality of life and functional capacity after lung transplantation: A single-center experience

Psychiatric disorders as risk factors for adverse medical outcomes after solid organ transplantation

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