Pre-treatment and treatment-Induced Neuron-specific Enolase in Patients with Small-Cell Lung Cancer: An Open Prospective Study

Erbaycu, Ahmet Emin; Gunduz, Ayriz; Batum, Özgür; Uçar, Zeynep Zeren; Tuksavul, Fevziye; Güçlü, Salih Zeki

doi:10.1016/s1579-2129(10)70086-0

Cited by 12 publications

(14 citation statements)

References 13 publications

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“…This may be explained by the fact that the majority of patients receiving this form of chemotherapy had SCC. Previous studies have identified NSE as a sensitive tumor marker for SCLC (10), but not for NSCLC (20,34). More recent results are contradictory.…”

Section: Discussionmentioning

confidence: 96%

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Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer

Pang

Wang

Jiang

et al. 2013

Experimental and Therapeutic Medicine

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Diagnostic tools capable of predicting early responses to chemotherapy are required to improve the individual management of cancer patients. The present study aimed to evaluate the prognostic significance of the serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), carbohydrate antigen (CA) 125, and CA 19-9 for predicting responses to different chemotherapy regimens in patients with non-small cell lung cancer (NSCLC). A total of 276 patients with postoperative stage I–IV NSCLC were retrospectively reviewed. The five tumor markers were measured before and after at least two cycles of chemotherapy using an electrochemiluminescent assay. Multivariate analysis revealed that performance status, age, postoperative stage and surgery were significantly associated with the response to chemotherapy. High baseline CYFRA 21-1 and CA 19-9 levels were associated with poor effectiveness of chemotherapy. Significant reductions in CYFRA 21-1 levels were associated with a positive response to various chemotherapy regimens. CEA, CA 125 and CA 19-9 expression was only associated with a positive response in patients receiving paclitaxel, docetaxel, pemetrexed and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). NSE expression was only associated with a positive response to gemcitabine. Receiver operating characteristic (ROC) curve analysis indicated that CYFRA 21-1 is the most sensitive of the tumor markers in predicting the response to chemotherapy. Serum CYFRA 21-1 is a useful surrogate marker for predicting the response to different chemotherapy regimens used to treat NSCLC and is a more sensitive marker than CEA, CA125, CA19-9 and NSE.

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Section: Discussionmentioning

confidence: 96%

“…The neuroendocrine marker neuron-specific enolase (NSE) is a glycolytic enzyme associated with high diagnostic sensitivity and specificity in small cell lung cancer (SCLC); however, its use in monitoring the effect of chemotherapy in NSCLC is controversial (10,11). …”

Section: Introductionmentioning

confidence: 99%

Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer

Pang

Wang

Jiang

et al. 2013

Experimental and Therapeutic Medicine

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“…Also, long-term exposure to PAHs had been reported to be associated with high incidence of lung cancer in coke oven workers (Wang et al, 2010;National Toxicology Program, 2011). As for serum tumor markers, including cytokeratin 19 fragments (Cyfra21-1), squamous cell carcinoma antigen (SCC) and neuron specific enolase (NSE), have been extensively studied in lung cancer (Niewoehner and Rubins, 2003;Emin et al, 2010;Chu et al, 2011). Accumulating evidence unravels the molecular mechanisms by which inflammatory responses promote tumor progression.…”

Section: Introductionmentioning

confidence: 99%

“…Tumor necrosis factor (TNF) a is one of the most potent pro-inflammatory cytokines produced in the tumor microenvironment (Takahashi et al, 2010). Earlier studies illustrated the significance of these tumor markers in the detection, prognosis and follow-up of lung cancer (Niewoehner and Rubins, 2003;Emin et al, 2010;Chu et al, 2011). However, the roles of these tumor markers in the diagnosis of coke oven workers are remain to be determined due to their relatively low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Gao

Chen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Earlier studies illustrated the significance of these tumor markers in the detection, prognosis and follow-up of lung cancer. [13][14][15][16][17][18][19] However, the roles of these tumor markers in the diagnosis of lung cancer are still controversial and remain to be determined due to their relatively low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Chu¹,

Hou²,

Song³

et al. 2011

Cancer Biology & Therapy

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Pre-treatment and treatment-Induced Neuron-specific Enolase in Patients with Small-Cell Lung Cancer: An Open Prospective Study

Cited by 12 publications

References 13 publications

Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer

Decreased levels of serum cytokeratin 19 fragment CYFRA 21-1 predict objective response to chemotherapy in patients with non-small cell lung cancer

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

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