Pre-treatment circulating neutrophil count is an independent prognostic factor in oropharyngeal cancer

Abstract

Background: Oropharyngeal cancer (OPC) is a type of head and neck squamous cell cancer, the incidence of which has increased in recent years. Many studies have reported a variety of prognostic markers of OPC, but they are either expensive or difficult to obtain. Therefore, we retrospectively studied the prognostic value of circulating neutrophil count (CNC) in patients with OPC, with the aim of providing a theoretical basis for further prognostic stratification. Methods:The clinicopathological data of 153 patients diagnosed with OPC from January 2010 to June 2017 were retrospectively analyzed. The CNC of each patient was measured before treatment. Then, the relationship between CNC and the clinicopathological characteristics of the patients was analyzed.The receiver operating characteristic (ROC) curve was used to calculate the cutoff value of CNC. The cox proportional hazards model was used to perform univariate and multivariate analysis of the relevant prognostic factors to determine the factors related to overall survival (OS) and progression-free survival (PFS). Results:The cutoff value for CNC was 4.48. Neutrophilia was significantly associated with disease stage, P16 status, and the type of therapy. In the univariate and multivariate analyses, CNC was found to be correlated with OS and PFS. Increased neutrophil count was predictive of poor OS (P<0.001) and PFS (P=0.001). Neutrophil count was an independent risk factor for OS (HR =2.09, 95% CI: 1.25-3.51, P=0.005) and PFS (HR =1.78, 95% CI: 1.10-2.88, P=0.02) in patients with OPC.Conclusions: Pre-treatment CNC is an independent prognostic factor for OPC.

Neutrophil to Lymphocyte Ratio in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

“…After sorting and removing duplicates, the abstracts of the remaining papers were reviewed, 26 of which were retrieved and reviewed in detail. Twelve studies that did not satisfy the inclusion criteria were discarded [27][28][29][30][31][32][33][34][35][36][37][38]. Of these, nine were excluded because they did not report the outcome of OPSCC separately from other locations of HNSCC [27][28][29][30][31][32]34,37,38], and three because they did not report the NLR value [33,35,36].…”

“…Twelve studies that did not satisfy the inclusion criteria were discarded [27][28][29][30][31][32][33][34][35][36][37][38]. Of these, nine were excluded because they did not report the outcome of OPSCC separately from other locations of HNSCC [27][28][29][30][31][32]34,37,38], and three because they did not report the NLR value [33,35,36]. Fourteen studies comprising 7647 patients with OPSCC were eventually selected in the analysis [13][14][15][16][17][18][19][20][21][22][23][24][25][26] (Figure 1).…”