Pre-treatment imaging and pathology characteristics of invasive breast cancers of limited extent: Potential relevance for MRI-guided localized therapy

The effect of age in breast conserving therapy: A retrospective analysis on pathology and clinical outcome data

“…A large research focus exists world-wide on genomic profiling and experimental study to understand the radiobiology of breast cancer [4,30,31], but very few studies address the prediction of tumor cell quantity [32]. We recommend that additional effort should be spent on predicting tumor cell quantity (e.g., building mathematic models to predict microscopic disease extension using multiple imaging modalities [13]) in order to design effective treatment plans for high-risk subgroup patients.…”

“…More than 1800 microscopic slides of invasive breast cancers in 60 patients (48 patients with age > 50 and 12 with age 6 50) were examined by two experienced breast cancer pathologists [12,13]. MSD was observed on the microscopic slides.…”

Accelerated partial irradiation for breast cancer: Systematic review and meta-analysis of 8653 women in eight randomized trials

“…Meanwhile, new issues concerning APBI are being explored, such as whether APBI could be performed in the preoperative scenario, if breast magnetic resonance imaging can be used to improve patients' selection, and if brachytherapy APBI schedule can be with a lesser number of fractions [62][63][64].…”

Shortened Radiation Therapy Schedules for Early-Stage Breast Cancer: A Review of Hypofractionated Whole-Breast Irradiation and Accelerated Partial Breast Irradiation

“…While the currently open and pending trials vary in terms of patient inclusion criteria and in how APBI is delivered, we expect that they will provide definitive information on whether APBI provides comparable local control and toxicity outcomes as WBI. In the interim, investigators are attempting to answer new questions regarding APBI, such as whether MRI can be used to better define patients who can be treated with APBI, brachytherapy‐based APBI can be delivered with fewer total fractions, or APBI should be delivered in the preoperative setting .…”