Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment

Cho, Hanbyoul; Hur, Hye Won; Kim, Sang Wun; Kim, Sung Hoon; Kim, Jae Hoon; Kim, Young Tae; Lee, Kook

doi:10.1007/s00262-008-0516-3

Cited by 482 publications

(423 citation statements)

References 34 publications

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“…[15][16][17] to explain neutrophilia include release of granulocyte-colony stimulating factor (G-CSF) by tumor cells, and cancer inflammation through release of interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-α). [18,19] Neutrophils are recruited by (G-CSF), which is associated with tumor progression. In addition, IL-6 also mobilizes neutrophils into a circulating pool and can be measured to predict cancer stage and oncological outcome.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Bolat

Aydoğdu

Polat

et al. 2017

Turkish Journal of Urology

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Objective: We investigated the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) on germ cell testicular tumors (GCT). Material and methods:The data of 53 patients who underwent inguinal orchiectomy were analyzed retrospectively. NLR was calculated from the preoperative complete blood cell counts. Receiver operating characteristic (ROC) analysis was performed to find the threshold values for NLR. Correlations between cancer-specific survival (CSS) and progression-free survival (PFS) and NLR were evaluated. Results:The mean follow-up time was 23.55±18.06 months. The mean level of NLR was 3.08±1.81. Optimal threshold values of NLR was calculated as 3.55 for PFS (area under curve, AUC: 0.55) and 3.0 for CSS (AUC: 0.66). For patients with a NLR of <3.55 and NLR of ≥3.55, mean times-to-progression were 55.71 months (95% CI, 51.27-60.14) and 51.95 months (95% CI, 38.02-65.87, p= 0.152), respectively. As well as, for patients with a NLR of <3.0 and NLR of ≥3.0, mean times -to-cancer specific death were 54.72 months (95% CI, 49.05-60.38) and 49.43 months (95% CI, 37.64-61.22, p= 0.119), respectively. Conclusion:Preoperative NLR is not a useful tool to predict the prognosis of patients with GCT.

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Section: Discussionmentioning

confidence: 99%

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Bolat

Aydoğdu

Polat

et al. 2017

Turkish Journal of Urology

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“…Generally, studies described that lymphopenia means an impaired cell-mediated immunity, while neutrophilia is linked response to systemic inflammation (Zahorec et al, 2001). Therefore neutrophil lymphocyte ratio (NLR) has been used not only as a marker of inflammation but also as a prognostic index for several types of malignancies (Halazun et al, 2008;Cho et al, 2009;Cedres et al, 2012). Therefore, the aim of this study was to assess the prognostic value of pretreatment neutrophil-to-lymphocyte ratio (NLR) in predicting survival in patients with colorectal cancer.…”

Section: Pretreatment Neutrophil/lymphocyte Ratio As a Prognostic Aidmentioning

confidence: 99%

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

Özdemi̇r¹,

Akın²,

Sücüllü³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Several recent studies have revealed a correlation between clinical outcomes with common solid tumors (colorectal cancer, lung cancer, breast cancer and pancreatic cancer, etc) and systemic inflammatory response, including plasma C-reactive protein (CRP), hypoalbuminemia, and a selective combination of C-reactive protein and albumin termed as Glasgow Prognostic Score (GPS) (Leitch et al, 2007;Hwang et al, 2011;Jiang et al, 2012;Fox et al, 2013;McMillan, 2013). There were also many studies reporting that haematological markers of systemic inflammatory response such as white blood cell count or its components (neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR)), platelet, and platelet-lymphocyte ratio (PLR) are also prognostic indicators for cancer clinical outcomes (Yamanaka et al, 2007;Cho et al, 2009;Kishi et al, 2009;Sarraf et al, 2009;Kwon et al, 2012;Dalpiaz et al, 2013;Fox et al, 2013). In addition, other inflammatory factor combinations such as Prognostic Index (PI) and Prognostic Nutritional Index (PNI) have also been linked with prognosis of malignancies (Kasymjanova et al, 2010;Nozoe et al, 2010;Kanda et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Li¹,

Lü²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR , GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.

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Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment

Abstract: Our findings provide evidence for the association between NLR and epithelial ovarian cancer. Preoperative NLR, in combination with CA125, may represent a simple and cost-effective method of identifying ovarian cancers, and an elevated NLR may predict an adverse outcome in ovarian cancer.

Cited by 482 publications

References 34 publications

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Predictive value of preoperative neutrophil-to-lymphocyte ratio on the prognosis of germ cell testicular tumors

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

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