Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: Possible relevance to the pathogenesis of preeclampsia

Objective Explore the association between following a Dietary Approaches to Stop Hypertension (DASH)-accordant diet and kidney end-points among urban adults. Design Prospective cohort study. Setting & Participants 1,534 participants of the Healthy Aging in Neighborhoods of Diversity across the Life Span study with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73m2. Exposure DASH diet accordance determined via a score based on 9 target nutrients. Main Outcome Measure Rapid kidney function decline (eGFR decline > 3 mL/min/1.73 m2 per year), incident CKD (follow-up eGFR <60 mL/min/1.73 m2), and eGFR decline ≥ 25% Measurements Multinomial logistic regression. Results Participants’ mean age was 48 years and 59% were African American. Median DASH score was 1.5 (range 0–8). Over a median of 5 years, 13.4% experienced rapid eGFR decline, including 15.2% among participants not following a DASH-accordant diet (score ≤1) and 12.0% with higher accordance (score >1) (p=0.08). Outcomes varied by hypertension status. Following adjustment for sociodemographic and clinical factors, including total energy intake, low DASH diet accordance was associated with rapid eGFR decline among participants with hypertension [Risk Ratio (RR) 1.68, 95% Confidence Interval (CI) 1.17–2.42] but not among those without hypertension (RR 0.83, 95% CI 0.56–1.24); p interaction 0.001. There was no statistically significant association between DASH diet accordance and incident CKD or eGFR decline ≥ 25%. Results were similar when DASH diet accordance was analyzed in tertiles. Conclusions Among urban adults, low accordance to a DASH-type diet was not associated with incident CKD, but was associated with higher risk of rapid eGFR decline among those with hypertension, yet not among those without hypertension. Further study of dietary patterns as a potential target for improving kidney outcomes among high-risk populations is warranted.

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“…Similar to magnesium, calcium has also been noted to have favorable effects on endothelial function. 38 …”

Section: Discussionmentioning

confidence: 99%

Dietary Habits and Risk of Kidney Function Decline in an Urban Population

Liu

Kuczmarski

Miller

et al. 2017

Journal of Renal Nutrition

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“…Calcium may protect endothelial cells from endothelial activation by multiple activators, including necrotic trophoblast debris and inflammatory cytokines, and prevent hypertension by increasing the production of nitric oxide, which is a potent vasodilator. 38 Additionally, low serum calcium could increase blood pressure by inducing parathyroid release, which stimulates renin release, resulting in increased intracellular calcium leading to vasoconstriction. 39,40 Indeed, calcium supplementation has been shown to substantially decrease the risk of preeclampsia based on data from randomized controlled trials, although publication bias cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Associations between late-onset preeclampsia and the use of calcium-based antacids and proton pump inhibitors during pregnancy: a prospective cohort study

Gelder¹,

Beekers²,

Rijt-Weetink

et al. 2022

Preprint

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Objective: To determine associations of calcium-based antacid and PPI use during pregnancy with late-onset preeclampsia (≥34 weeks of gestation), taking into account dosage and timing of use. Design: Prospective cohort study. Setting: This study used data from the PRIDE Study (2012-2019) and Dutch Pregnancy Drug Register (2014-2019). Sample: A total of 9,058 pregnant Dutch women aged ≥18 years. Methods: Data were collected through web-based questionnaires and obstetric records. We estimated risk ratios (RRs) for late-onset preeclampsia for any use and trajectories of calcium-based antacid and PPI use before gestational day 238, and hazard ratios for time-varying exposures after gestational day 237. Main outcome measure: Late-onset preeclampsia. Results: Late-onset preeclampsia was diagnosed in 2.6% of pregnancies. Any use of calcium-based antacids (RR 1.2 [95% CI 0.9-1.6]) or PPIs (RR 1.4 [95% CI 0.8-2.4]) before gestational day 238 was not associated with late-onset preeclampsia. Use of low-dose calcium-based antacids in gestational weeks 0-16 (<1g/day; RR 1.8 [95% CI 1.1-2.9]) and any use of PPIs in gestational weeks 17-33 (RR 1.6 [95% CI 1.0-2.8]) seemed to increase risks of late-onset preeclampsia. We did not observe associations between late-onset preeclampsia and use of calcium-based antacids and PPIs after gestational day 237. Conclusions: In this prospective cohort study, use of calcium-based antacids and PPIs during pregnancy was not found to reduce the risk of late-onset preeclampsia. Funding: Netherlands Organisation for Health Research and Development [ZonMw; grant number 848018010].

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“…Since SNAs are as yet difficult to harvest from maternal blood, we have used readily accessible SNAs obtained from a placental explant model [29,[40][41][42] to assessed the quantity and quality of the DNA content of SNAs and the utility of this material for genetic diagnostics. The…”

Section: Discussionmentioning

confidence: 99%

Detection of Fetal Sex, Aneuploidy and a Microdeletion from Single Placental Syncytial Nuclear Aggregates

Holland

Kroneis²,

El‐Heliebi³

et al. 2016

Fetal Diagn Ther

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Objectives: A key problem in prenatal screening using extra-embryonic cells is the feasibility of extracting usable DNA from a small number of cells. Syncytial nuclear aggregates (SNAs) are multinucleated structures shed from the placenta. This study assesses the potential of SNAs as a source of fetal DNA for the detection of genetic abnormalities. Methods: SNAs were collected in vitro. Whole-genome amplification was used to amplify DNA from single SNAs, and DNA quality and quantity was assessed by spectrophotometry and PCR. Confocal microscopy was used to count nuclei within SNAs, determine metabolic activity and investigate DNA damage. Fetal sex and chromosomal/genetic abnormalities were investigated with array-comparative genomic hybridization (aCGH). Results: DNA was amplified from 81% of the individual SNAs. A mean of 61 ± 43 nuclei were found per SNA. DNA strand breaks were found in 76% of the SNAs. Seventy-five percent of SNAs yielded whole-genome-amplified DNA of sufficient quality for aCGH after storage and shipping. Individual SNAs from the same pregnancy reliably gave the same chromosomal profile, and fetal sex and trisomies could be detected. A microdeletion was detected in one pregnancy. Conclusion: SNAs could provide a source of extra-embryonic DNA for the prenatal screening/diagnosis of fetal sex and chromosomal and sub-chromosomal genetic abnormalities.

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Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: Possible relevance to the pathogenesis of preeclampsia

Cited by 13 publications

References 24 publications

Dietary Habits and Risk of Kidney Function Decline in an Urban Population

Dietary Habits and Risk of Kidney Function Decline in an Urban Population

Associations between late-onset preeclampsia and the use of calcium-based antacids and proton pump inhibitors during pregnancy: a prospective cohort study

Detection of Fetal Sex, Aneuploidy and a Microdeletion from Single Placental Syncytial Nuclear Aggregates

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