Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer

Esfahani, Ali; Makhdami, Nima; Faramarzi, Elnaz; Jafarabadi, Mohammad Asghari; Ostadrahimi, Alireza; Nahand, Mousa Ghayour; Ghoreishi, Zohreh

doi:10.1155/2016/4686189

Cited by 23 publications

(21 citation statements)

References 19 publications

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“…[3][4][5] To examine whether the same may be true of patients with HCC who undergo potentially curative hepatectomy, we performed a retrospective analysis of patients at our hospital. Serum prealbumin has already been linked to prognosis of patients with acute leukemia or with colorectal, esophageal, ovarian, lung, or stomach cancers.…”

Section: Introductionmentioning

confidence: 99%

Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy

Jia

Zhong

Huo

et al. 2019

Journal of Surgical Oncology

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Objective To determine whether serum prealbumin levels are associated with long‐term survival after hepatectomy in patients with primary hepatocellular carcinoma(HCC). Methods A consecutive sample of 526 patients with HCC who underwent potentially curative hepatectomy from August 2007 to August 2010 was retrospectively analyzed. Patients were classified as having normal or reduced serum prealbumin based on cut‐off values of 200 or 182 mg/L. Results Multivariate analysis identified the preoperative level of serum prealbumin as an independent prognostic factor of long‐term survival (P < 0.05): Survival was significantly better for those with normal levels than for those with reduced levels, based on either cut‐off value. Similar results were observed in subgroup analyses based on the degree of cirrhosis, level of ɑ‐fetoprotein and Barcelona Clinic Liver Cancer stage. Conclusions Preoperative level of serum prealbumin may be useful for predicting long‐term survival in patients with HCC after hepatectomy.

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Section: Introductionmentioning

confidence: 99%

Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy

Jia

Zhong

Huo

et al. 2019

Journal of Surgical Oncology

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“…Liver and renal dysfunction, inflammation and malnutrition can also fluctuate the level of serum PA. 12,13 Researches show that PA is related to the prognosis of lots of disease, such as gastric cancer, adenocarcinoma of oesophagogastric junction and hemodialysis. [14][15][16][17][18][19] The relationship between the PA and lung disorders, including IPF, remains unclear. In this study, we aimed to test the usefulness of PA in IPF outcome.…”

Section: Introductionmentioning

confidence: 99%

Serum prealbumin is a prognostic indicator in idiopathic pulmonary fibrosis

Zhang

et al. 2019

Clinical Respiratory J

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Introduction Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by variable progression. The prealbumin (PA) is a parameter in a routine blood biochemistry examination. We sought to investigate the prognostic value in IPF patients. Objectives To evaluate the prognosis value in patients with IPF. Methods Blood biochemistry examination, demographics, pulmonary function data from patients with IPF consulted in Beijing Chao‐Yang Hospital and China‐Japan Friendship Hospital between July 2012 and December 2016 were collected. Infection, liver and kidney dysfunction and lung transplantation are excluded from the cohort. Results The result of multivariate Cox analysis showed that PA was significant prognostic indicator of survival along with BMI, FVC, serum albumin protein and serum global protein. The patients with PA concentration <0.2 mg/L had shorter survival compared with those whose PA were normal. Although the survival had no significant difference between the patients with PA concentration < 0.2 mg/L and albumin < 35 g/L and those with PA concentration < 0.2 mg/L, the average survival time of patients with PA concentration < 0.2 mg/L and albumin < 35 g/L were shorter. Conclusions Our study indicated that IPF patients with PA concentration < 0.2 mg/L have poorer outcome. Further studies are warranted to indentify PA as a predictor for IPF patients outcomes and explore the role of PA in the pathogenesis of IPF.

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“…15 Sensitivity and specificity of decreased pre-albumin levels for predicting metastases in inoperable patients were found to be 77.1% and 52.2%, respectively was observed. Moreover, the authors argued that the pre-albumin/CRP ratio could be a more useful predictor of metastasis.…”

Section: Discussionmentioning

confidence: 87%

Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer

Rao¹,

Phanikumar²,

Kumar³

2017

Int Surg J

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Background: malnutrition and systemic inflammatory response in cancers result in a shorter survival rate, reduced treatment response and a higher rate of complications associated with therapy. Prealbumin, albumin and CRP Levels has utility as a prognostic indicator of cancer survival in cancer. The objective of this study was to albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer were prospectively recorded and retrospectively evaluated.Methods: Study was done for period of 1 year in patients underwent surgery for gastric cancer. Details noted from records are as age, gender, duration of hospital stay, TNM stage, and preoperative albumin, pre-albumin and CRP levels.Results: A total number of 44 patients, 32 (72.7%) men and 12 (27.7%) women, were included in the study. The mean age was 64.1 (43-89) years. The mean duration of hospital stay was 12.8 (4-46) days. Preoperative albumin levels were below the expected range in 16 (41%) of 44 patients. Mean age of the patients with normal and decreased albumin levels was 62.7±12.8 and 65.3±12.3 years, respectively; albumin levels were insignificantly associated with the age (p = 0.54). When these 16 cases were evaluated in terms of disease stage-3 had 11(68.7%). Preoperative pre-albumin levels were decreased in 23 (53%) of 44 cases. Among the cases with decreased pre-albumin levels, stage 1 and 3 had 5 (21.7%) cases. There was a significant correlation between the TNM stage and pre-albumin levels (P = 0.014). CRP levels were elevated in 19 (43.2%) of 44 cases with CRP. Among these Stage-3 had 8 cases, 4 (42.1%). There was no significant correlation between disease stage, presence of metastatic lymph nodes and albumin levels (p>0.05).Conclusions: Preoperative albumin, pre-albumin and CRP levels can be useful to predict prognosis of patients with gastric cancer.

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Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer

Cited by 23 publications

References 19 publications

Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy

Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy

Serum prealbumin is a prognostic indicator in idiopathic pulmonary fibrosis

Albumin, prealbumin and CRP levels can be used to predict prognosis in gastric cancer

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