1989
DOI: 10.1111/j.1365-2710.1989.tb00249.x
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Preanalytical Considerations in Drug Assays in Clinical Pharmacokinetic Studies

Abstract: SUMMARYMany hospital pharmacy laboratories undertake drug analysis in biological fluids for the production of pharmacokinetic data. The success of such an undertaking very much depends on the selection of a suitable analytical method and a proper approach to sample collection and handling. This paper surveys the main types of biological specimens taken from the patients for pharmacokinetic drug analysis and discusses factors that affect them during or subsequent to their removal. Guidelines are provided in spe… Show more

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Cited by 5 publications
(1 citation statement)
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“…It is essential that the samples are collected in a suitable container at the correct time in relation to the dose and correctly labelled and preserved under appropriate conditions. [69][70][71][72] Sample identity should include the source of samples, dosage, sampling time in relation to the dose and date and the drug(s) to be assayed. In drug bioanalysis, as sampling frequently is not under the control of the analyst performing the assay, it is necessary to issue clear instructions to the sample provider for collection, storage and transport of samples.…”
Section: Samplesmentioning
confidence: 99%
“…It is essential that the samples are collected in a suitable container at the correct time in relation to the dose and correctly labelled and preserved under appropriate conditions. [69][70][71][72] Sample identity should include the source of samples, dosage, sampling time in relation to the dose and date and the drug(s) to be assayed. In drug bioanalysis, as sampling frequently is not under the control of the analyst performing the assay, it is necessary to issue clear instructions to the sample provider for collection, storage and transport of samples.…”
Section: Samplesmentioning
confidence: 99%