Prebiotic and antimicrobials on performance, carcass characteristics, and antibody production in broilers

Fomentini, Maíra; Haese, Douglas; Kill, João Luís; Sobreiro, Rodrigo Pereira; Puppo, Débora Del; Haddade, Ismail Ramalho; Lima, Anderson Lazarini; Saraiva, Alysson

doi:10.1590/0103-8478cr20150133

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…The dose-dependent and saturable nature of adhesion inhibition by RFC in our cell culture model suggests specific receptor–ligand binding reactions may contribute to reduced adhesion of bacteria to epithelial cells. Mannose binding of FimH-like adhesins on type 1 fimbriae has been demonstrated to inhibit epithelial cell adhesion of gram-negative bacteria, including Salmonella and E. coli ( Oyofo et al., 1989 ; Spring et al., 2000 ) and has been suggested to reduce GI colonization ( Fomentini et al., 2016 ). Although similar adhesins have not been identified in Campylobacter spp., mannose-binding lectins have been observed in C. jejuni 11168 ( Day et al., 2009 ), suggesting analogous binding interactions may also be involved in Campylobacter reduction.…”

Section: Resultsmentioning

confidence: 99%

Refined functional carbohydrates reduce adhesion of Salmonella and Campylobacter to poultry epithelial cells in vitro

Froebel

Duong

2020

Poultry Science

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The development of interventions to reduce human foodborne pathogens in the gastrointestinal ( GI ) tract of chickens will be important for improving the microbial food safety of poultry. Saccharomyces -derived prebiotic refined functional carbohydrates ( RFC ), composed primarily of β-glucans, mannanoligosaccharides ( MOS ), and D-mannose have been demonstrated to reduce GI colonization of Salmonella and Campylobacter when administered to poultry. Although they are presumed to inhibit adhesion of pathogens to the GI epithelium, this functionality of RFC has not been well characterized. In this study, we investigated the effects of RFC and other prebiotics on the adhesion of Salmonella Typhimurium and Campylobacter jejuni to the LMH chicken epithelial cell line in vitro. The reduction of adherent pathogens was observed to be dose-dependent with C. jejuni being more sensitive than Salmonella to inhibition by RFC. Comparison of the primary constituent carbohydrates of RFC found D-mannose to inhibit both pathogens less effectively than β-glucan and MOS, suggesting that it contributes less to inhibition of pathogen adhesion than the other carbohydrates. Finally, the reduction of adherent pathogens by RFC was compared with that of fructooligosaccharides ( FOS ), galactooligosaccharides ( GOS ), and raffinose. All 4 prebiotics inhibited adhesion of both pathogens to chicken epithelial cells. Reduction of adherent Salmonella was greatest with FOS and lowest with GOS, whereas reduction of adherent C. jejuni was greater with RFC and raffinose than with FOS and GOS. These results will inform future research elucidating mechanisms important to adhesion inhibition of pathogens by RFC and other prebiotics.

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Section: Resultsmentioning

confidence: 99%

Refined functional carbohydrates reduce adhesion of Salmonella and Campylobacter to poultry epithelial cells in vitro

Froebel

Duong

2020

Poultry Science

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“…Hydrolysis of the α-(1 → 6) bond present in the mannan of yeast cell walls produces α-MOS, whereas plant mannans linked by β-(1 → 4)-glycosidic bonds are broken down to release mainly β-MOS (Ayimbila and Keawsompong, 2022). This compound favors beneficial bacteria selectively since most pathogens cannot use it as an energy source (Fomentini et al, 2016). Furthermore, MOS agglutinate gram-negative bacteria that have type 1 fimbriae in their cell walls, preventing them from attaching to the intestinal mucosa and initiating proliferation; consequently, they are eliminated in the excreta (Spring et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Effect of the use of prebiotics, alone and in combination with antibiotics, in broiler diets

Martins,

Mello,

Mascarenhas

et al. 2024

Revista Brasileira De Zootecnia

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Non-ruminantsFull-length research article Effect of the use of prebiotics, alone and in combination with antibiotics, in broiler diets ABSTRACT -The objective of this study was to evaluate the effects of prebiotics, alone and in combination with antibiotics, on broiler performance, carcass yield, intestinal permeability, and intestinal morphometry. A total of 1440 day-old male Cobb 500 chicks were distributed in a completely randomized design, with four treatments and 10 replications per treatment. The treatments used were a basal diet without prebiotics and antibiotics (BD), a basal diet with antibiotics (AB), a basal diet with prebiotics (PRE), and a basal diet with antibiotics and prebiotics (AB+PRE). To perform the treatment, the antibiotic zinc bacitracin and a prebiotic of S. cerevisiae-derived mannan-oligosaccharides and beta-glucans were used. The treatments did not affect the performance of birds from 1 to 7 and 1 to 21 days of age. From 1 to 35 and 1 to 42 days, birds fed the AB+PRE treatment had higher feed intake than those fed the AB treatment. From 1 to 35 days, birds fed the AB+PRE treatment showed a worse feed conversion ratio. However, there was no difference in carcass yield between treatments. A higher number of goblet cells was observed in the duodenum and ileum of birds fed AB+PRE, but lower counts were obtained in birds fed AB. Intestinal histomorphometry displayed similar responses between both ages regarding antibiotic and prebiotic treatments, except in the ileum at 42 days, in which the antibiotic elicited a better response. Intestinal permeability analysis showed no significant difference between diets. The use of prebiotics, alone or in combination with antibiotics, does not improve the performance of broilers.

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“…Halquinol (HAL), a powerful non-antibiotic antimicrobial agent, is widely used in the poultry industry as a primary growth promotor with antimicrobial, antifungal, and antiprotozoal effects (Maira et al, 2016;Habib et al, 2019). Because of its broad spectrum of activity and ability to regulate peristalsis in the intestines, HAL is useful in addressing malabsorption disorders (Kandepu et al, 2012;Nischal et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Halquinol (HAL) on Growth Performance, Carcass Traits and Blood-lipid Profile in Broiler Chickens

2024

IJAB

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Article HistoryA global trend towards removing antibiotic growth promoters (AGPs) from animals reduces intestinal diseases and contributes to the investigation of effective production-sustaining methods in the post-AGP era. Thus, halquinol (HAL) has been used to improve gut health and efficacy. The present study was carried out to evaluate the efficacy of HAL as a substitute for AGPs in broiler chickens. A total of 240 seven-days-old SPF broiler chickens were randomly assigned to four dietary groups and each with twenty birds. The groups were: T0 (control), BD

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Prebiotic and antimicrobials on performance, carcass characteristics, and antibody production in broilers

Cited by 9 publications

References 12 publications

Refined functional carbohydrates reduce adhesion of Salmonella and Campylobacter to poultry epithelial cells in vitro

Refined functional carbohydrates reduce adhesion of Salmonella and Campylobacter to poultry epithelial cells in vitro

Effect of the use of prebiotics, alone and in combination with antibiotics, in broiler diets

The Effect of Halquinol (HAL) on Growth Performance, Carcass Traits and Blood-lipid Profile in Broiler Chickens

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