Prebiotic effect of dietary polyphenols: A systematic review

Alves‐Santos, Aline Medeiros; Sugizaki, Clara Sandra de Araújo; Lima, Gláucia Carielo; Naves, Maria Margareth Veloso

doi:10.1016/j.jff.2020.104169

Cited by 196 publications

(131 citation statements)

References 78 publications

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“…The high number of polyphenols in pâté samples resisting enzymatic digestion and remaining covalently joined to the cell wall could arrive to the colon and modulate the intestinal microbiome’s composition [ 14 , 15 ]. Several works have pointed out the relevance of intestinal microbiota in generating polyphenol metabolites, which are better absorbed than the precursor polyphenols, showing more bioactivity and persisting longer in blood [ 74 , 75 ].…”

Section: Resultsmentioning

confidence: 99%

“…Recently, many investigations have pointed out that polyphenols, especially in their insoluble-bound form, which remains covalent joining the cell wall, could modulate the intestinal microbiome’s composition [ 14 , 15 ]. Furthermore, some authors pointed out the potential of polyphenol-biofortified food as a novel tool for preventing human gut diseases [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Pork Liver Pâté Enriched with Persimmon Coproducts: Effect of In Vitro Gastrointestinal Digestion on Its Fatty Acid and Polyphenol Profile Stability

2021

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Agrofood coproducts are used to enrich meat products to reduce harmful compounds and contribute to fiber and polyphenol enrichment. Pork liver pâtés with added persimmon coproducts (3 and 6%; PR-3 and PR-6, respectively) were developed. Therefore, the aim was to study the effect of their in vitro gastrointestinal digestion on: the free and bound polyphenol profile (HPLC) and their colon-available index; the lipid oxidation (TBARs); and the stability of the fatty acid profile (GC). Furthermore, the effect of lipolysis was investigated using two pancreatins with different lipase activity. Forty-two polyphenols were detected in persimmon flour, which were revealed as a good source of bound polyphenols in pâtés, especially gallic acid (164.3 µg/g d.w. in PR-3 and 631.8 µg/g d.w. in PR-6). After gastrointestinal digestion, the colon-available index in enriched pâté ranged from 88.73 to 195.78%. The different lipase activity in the intestinal phase caused significant differences in bound polyphenols’ stability, contributing to increased lipid oxidation. The fatty acids profile in pâté samples was stable, and surprisingly their PUFA content was raised. In conclusion, rich fatty foods, such as pâté, are excellent vehicles to preserve bound polyphenols, which can reach the colon intact and be metabolized by the intestinal microbiome.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pork Liver Pâté Enriched with Persimmon Coproducts: Effect of In Vitro Gastrointestinal Digestion on Its Fatty Acid and Polyphenol Profile Stability

2021

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“…Polyphenols have been suggested to be a prebiotic, although this statement remains controversial. While it is recognized that polyphenols can modulate the microbial composition, evidence of prebiotic functions remains inconclusive [ 50 ]. In animal studies polyphenols such as catechins, anthocyanins and proanthocyanidins have been shown to increase what are considered as pro-health bacterial strains; Lactobacillus, Bifidobacterium, Akkermansia, Roseburia, and Faecalibacterium spp [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of a Dried Fruit and Vegetable Supplement and Fiber Rich Shake on Gut and Health Parameters in Female Healthcare Workers: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial

et al. 2021

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Aim: Phytochemicals from fruits and vegetables are known to reduce inflammation and improve overall health. The objective of this study was to determine the effect of a fruit and vegetable concentrate (FVC) and high fiber component on the gut microbiome in an overweight/obese, female population. Methods: The study was a randomized, double blind, placebo-controlled trial with 57 asymptomatic, pre-menopausal, overweight/obese females between 25–50 years of age working in healthcare. Blood and fecal samples were collected before and after two, four and five months of daily supplementation. Metabolic parameters were measured, and the gut microbiome analyzed. Results: No effect was observed with FVC supplementation for blood lipids, glucose and immune parameters. There was an improvement in glucose clearance. The FVC supplement did not result in taxonomic alterations at phyla level, or changes in α or β diversity, but reduced Bacteroides abundance and increased fecal butyrate. An additional high fiber component improved levels of health associated bacteria. Conclusion: The results suggest that a dried fruit and vegetable supplement, with a high fiber meal replacement can alter the intestinal microbiota and improve glucose clearance, suggesting that this combination of supplements can improve glucose metabolism and possibly reduce the risk of insulin resistance.

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“…In some cases, an imbalance in the individual’s intestinal flora may be a highly contributing factor to these conditions. Regarding this, in vivo studies have shown that the oral administration of polyphenols, namely catechins, anthocyanins, and procyanidins, simulate the growth of prebiotics microorganisms, e.g., Lactobacillus, Bifidobacterium, Akkermansia, Roseburia , and Faecalibacterium spp, which lead to a reduction of fat mass, liver steatosis, body weight gain, and also to the regularization of glucose metabolism [ 90 ].…”

Section: Polyphenols and Healthmentioning

confidence: 99%

Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

Câmara

Albuquerque

Aguiar

et al. 2020

Foods

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Experimental studies have provided convincing evidence that food bioactive compounds (FBCs) have a positive biological impact on human health, exerting protective effects against non-communicable diseases (NCD) including cancer and cardiovascular (CVDs), metabolic, and neurodegenerative disorders (NDDs). These benefits have been associated with the presence of secondary metabolites, namely polyphenols, glucosinolates, carotenoids, terpenoids, alkaloids, saponins, vitamins, and fibres, among others, derived from their antioxidant, antiatherogenic, anti-inflammatory, antimicrobial, antithrombotic, cardioprotective, and vasodilator properties. Polyphenols as one of the most abundant classes of bioactive compounds present in plant-based foods emerge as a promising approach for the development of efficacious preventive agents against NCDs with reduced side effects. The aim of this review is to present comprehensive and deep insights into the potential of polyphenols, from their chemical structure classification and biosynthesis to preventive effects on NCDs, namely cancer, CVDs, and NDDS. The challenge of polyphenols bioavailability and bioaccessibility will be explored in addition to useful industrial and environmental applications. Advanced and emerging extraction techniques will be highlighted and the high-resolution analytical techniques used for FBCs characterization, identification, and quantification will be considered.

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Prebiotic effect of dietary polyphenols: A systematic review

Cited by 196 publications

References 78 publications

Pork Liver Pâté Enriched with Persimmon Coproducts: Effect of In Vitro Gastrointestinal Digestion on Its Fatty Acid and Polyphenol Profile Stability

Pork Liver Pâté Enriched with Persimmon Coproducts: Effect of In Vitro Gastrointestinal Digestion on Its Fatty Acid and Polyphenol Profile Stability

The Impact of a Dried Fruit and Vegetable Supplement and Fiber Rich Shake on Gut and Health Parameters in Female Healthcare Workers: A Placebo-Controlled, Double-Blind, Randomized Clinical Trial

Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

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