Prebiotic ingestion does not improve gastrointestinal barrier function in burn patients

Olguin, F Garcia; Araya, Magdalena; Hirsch, Sandra; Brunser, O; Ayala, V Pérez de; Rivera, Rene; Gotteland, Martín

doi:10.1016/j.burns.2004.11.017

Cited by 39 publications

(28 citation statements)

References 33 publications

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“…17,25,29 Those clinical situations are clearly more severe than the mild biochemical cholestasis in our patients, who also had a less prominent increase in L/M ratio.…”

Section: Discussionmentioning

confidence: 89%

“…13,[15][16][17]25 Sucrose was added to the lactulose/ mannitol solution as a permeability probe for absorption through the stomach and proximal duodenum. [27][28][29][30][31][32][33] Permeability tests were carried out starting at 08:00 to 09:00 AM. After an overnight fast, each person was asked to empty her bladder completely and then to drink a 450-mL solution containing 40 g sucrose, 7.5 g lactulose, and 2 g mannitol.…”

Section: Methodsmentioning

confidence: 99%

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Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?†‡§

et al. 2006

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I ntrahepatic cholestasis of pregnancy (ICP) is a rare disorder of unknown cause that may develop during the third or second trimester of pregnancy and resolves rapidly after delivery. The chief complaint is pruritus, and serum liver tests reveal a mild cholestasis with increased levels of bile salts and aminotransferases. ICP may cause fetal distress, with stillbirths or premature deliveries leading to increased perinatal morbidity and mortality. 1,2 The pathogenesis of ICP appears to be multifactorial. Potential contributors include a genetic predisposition interacting with the effects of estrogen and progesterone metabolites on bile secretory mechanisms. 3 The influence of environmental factors has been suggested by the observation of a seasonal variability in the incidence of ICP, with highest rates reported during winter, a recurrence rate of only 45% to 70% in subsequent pregnancies of multiparous women, and the decrease in the prevalence of ICP detected in Sweden and Chile during recent decades. 4 Therefore, identifying factors that may explain these epidemiological changes appear to be important.The gastrointestinal mucosal epithelium is an essential barrier that normally restricts the passage of harmful molecules into the mucosa and systemic circulation. An increased intestinal permeability has been observed in patients with enteric damage, such as in inflammatory From the

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“…17,25,29 Those clinical situations are clearly more severe than the mild biochemical cholestasis in our patients, who also had a less prominent increase in L/M ratio.…”

Section: Discussionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?†‡§

et al. 2006

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“…An additional RCT was excluded because of repeated data 21 . Finally, 5 RCTs that met our inclusion criteria were included in the present meta‐analysis 22 – 26 . The flowchart of studies included in the meta‐analysis is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Probiotics in Early Enteral Nutrition on the Outcomes of Trauma

Deng

Gong

et al. 2012

J Parenter Enteral Nutr

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“…Based on the diagnostic criteria for MODS and GI symptoms commonly seen in burned patients, GI dysfunction is summarized as follows: (1) abdominal distension: bowel sound was reduced and food intolerance exceeded more than 5 d; (2) stress ulcer: gastric fluid aspirated from the gastric tube appeared bloody macroscopically and gastric mucosa was erosive and ulcerative gastroendoscopically; (3) severe stress ulcer: blood loss exceeded 800 mL within 24 h; (4) alteration of intestinal microbiota: Gramnegative E.coli was amplified, and the bacillus/coccus ratio was greater than 10:1; and (5) enterogenic infection: highly suspected systemic infection occurred after ruling out wound surface, pulmonary and indwelling catheter infections [9,10] .…”

Section: Indexes For Assessing Gi Functionmentioning

confidence: 99%

Prevention and treatment of gastrointestinal dysfunction following severe burns: A summary of recent 30-year clinical experience

Xiao¹,

Zhu²,

Xia³

et al. 2008

WJG

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(P < 0.05 or P < 0.01), and the occurrence of stress ulcer was also significantly lower than that in stage 2 patients (P < 0.05). CONCLUSION: Comprehensive fluid resuscitation, early excision of necrotic tissue, staged food ingestion, and administration of specific nutrients are essential strategies for preventing gastrointestinal complications and lowering mortality in severely burned patients. INTRODUCTIONGastrointestinal dysfunction is a common complication of severe burns. Injury to GI function, especially to GI barrier function, is an important initiator as well as a stimulator for occurrence of systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) following severe burns [1] . With the deeper understanding of GI function and changes in the stereotype of clinical treatment in recent 30 years, a series of new therapies including fluid resuscitation, early escharectomy, continuous renal replacement therapy, and use of glutamine and growth factor has been adopted in the treatment of severe burns [2,3] . Although animal experiments have shown that these new therapies do play a positive role in the prevention and treatment of GI dysfunction following severe burns, there has been a lack of convincing clinical Abstract AIM: To sum up the recent 30-year experience in the prevention and treatment of gastrointestinal dysfunction in severe burn patients, and propose practicable guidelines for the prevention and treatment of gastrointestinal (GI) dysfunction. METHODS: From 1980 to 2007, a total of 219 patients with large area and extraordinarily large area burns (LAB) were admitted, who were classified into three stages according the therapeutic protocols used at the time: Stage 1 from 1980 to 1989, stage 2 from 1990 to 1995, and stage 3 from 1996 to 2007. The occurrence and mortality of GI dysfunction in patients of the three stages were calculated and the main causes were analyzed. RESULTS: The occurrence of stress ulcer in patients with LAB was 8.6% in stage 1, which was significantly lower than that in stage 1 (P < 0.05). No massive hemorrhage from severe stress ulcer and enterogenic infections occurred in stages 2 and 3. The occurrence of abdominal distension and stress ulcer and the mortality in stage 3 patients with extraordinarily LAB was 7.1%, 21.4% and 28.5%, respectively, which were significantly lower than those in stage 1 patients

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Prebiotic ingestion does not improve gastrointestinal barrier function in burn patients

Cited by 39 publications

References 33 publications

Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?†‡§

Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?†‡§

The Effects of Probiotics in Early Enteral Nutrition on the Outcomes of Trauma

Prevention and treatment of gastrointestinal dysfunction following severe burns: A summary of recent 30-year clinical experience

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