Prebiotic potential of polyphenols, its effect on gut microbiota and anthropometric/clinical markers: A systematic review of randomised controlled trials

Moorthy, Mohanambal; Chaiyakunapruk, Nathorn; Jacob, Sabrina Anne; Palanisamy, Uma Devi

doi:10.1016/j.tifs.2020.03.036

Cited by 80 publications

(62 citation statements)

References 88 publications

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“…A recent review and meta-analysis of randomized controlled trials supports the prebiotic action of polyphenols, capable of modulating and improving intestinal microbe populations, which affects to CVD and colorectal cancer markers [132]. Furthermore, another randomized controlled trial showed that the ingestion of VOO enriched with phenolic compounds decreases the serum levels of oxidized LDL in hypercholesterolemic participants as well as increases the presence of Bifidobacterium spp in feces.…”

Section: Positive Modulation Of Gut Microbiotamentioning

confidence: 97%

“…Nevertheless, many attributes of EVOO are also related to the MED, the context in which its beneficial effects have been mainly evaluated. Polyphenols exert a prebiotic action on gut microbiota, improving also CVD and CRC [132] EVOO: extra virgin olive oil; CVD: cardiovascular disease; CHD: coronary heart disease; RCT: randomized controlled trial; MED: Mediterranean diet; HDL: high-density lipoprotein; LDL: low-density lipoprotein; IL-6: interleukin-6; CRP: C-reactive protein; TNF-α: tumor necrosis factor alpha; IBD: inflammatory bowel disease; ERN: estrogen receptor negative; CRC: colorectal cancer.…”

Section: Biological Properties Of Evoomentioning

confidence: 99%

“…It is estimated that 90-95% of total phenolic compounds intake is not absorbed in the small intestine; therefore, they remain in the large intestinal lumen where they are subjected to gut microbiota metabolic activities. As a consequence, polyphenols are converted to low-molecular-weight compounds that are absorbed and responsible for the health benefits derived from polyphenol-rich food, such as EVOO [132,146,147].…”

Section: Positive Modulation Of Gut Microbiotamentioning

confidence: 99%

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Bioactive Compounds and Quality of Extra Virgin Olive Oil

Jiménez-López

Carpena

Gallardo-Gómez

et al. 2020

Foods

315

235

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(1) Background: Extra virgin olive oil (EVOO) is responsible for a large part of many health benefits associated to Mediterranean diet as it is a fundamental ingredient of this diet. The peculiarities of this golden, highly valued product are in part due to the requirements that must be met to achieve this title, namely, it has to be obtained using exclusively mechanical procedures, its free acidity cannot be greater than 0.8%, it must not show sensory defects, and it has to possess a fruity taste. (2) Methods: All these characteristics are key factors to EVOO quality, thus the chemical composition of these many health-promoting compounds, such as unsaturated fatty acids (which are also the major compounds, especially oleic acid), as well as minor components such as tocopherols or phenolic compounds (which behave as natural antioxidants) must be preserved. (3) Results: Due to the presence of all these compounds, the daily consumption of EVOO entails health benefits such as cardioprotective, antioxidant, anti-inflammatory, anti-tumor properties or acting as regulator of the intestinal microbiota, among others. (4) Conclusions: Taking all together, conserving EVOO chemical composition is essential to preserve its properties, so it is worth to control certain factors during storage like exposure to light, temperature, oxygen presence or the chosen packaging material, to maintain its quality and extend its shelf-life until its consumption.

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Section: Positive Modulation Of Gut Microbiotamentioning

confidence: 97%

Section: Biological Properties Of Evoomentioning

confidence: 99%

Section: Positive Modulation Of Gut Microbiotamentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Jiménez-López

Carpena

Gallardo-Gómez

et al. 2020

Foods

315

235

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“…Human intervention studies may further provide a better model for studying the effect of polyphenol on gut microbiota and immunometabolism modulation. To date, only a few human intervention studies have investigated the in vivo impact of polyphenols on the gut microbiota [ 235 , 236 , 237 , 238 ]. However , in vivo human studies also hold inevitable limitations including applied microbial techniques.…”

Section: Effect Of Polyphenols On the Composition Of Gut Microbiotmentioning

confidence: 99%

Involvement of Gut Microbiota, Microbial Metabolites and Interaction with Polyphenol in Host Immunometabolism

Man¹,

Zhou²,

Xia³

et al. 2020

Nutrients

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Immunological and metabolic processes are inextricably linked and important for maintaining tissue and organismal health. Manipulation of cellular metabolism could be beneficial to immunity and prevent metabolic and degenerative diseases including obesity, diabetes, and cancer. Maintenance of a normal metabolism depends on symbiotic consortium of gut microbes. Gut microbiota contributes to certain xenobiotic metabolisms and bioactive metabolites production. Gut microbiota-derived metabolites have been shown to be involved in inflammatory activation of macrophages and contribute to metabolic diseases. Recent studies have focused on how nutrients affect immunometabolism. Polyphenols, the secondary metabolites of plants, are presented in many foods and beverages. Several studies have demonstrated the antioxidant and anti-inflammatory properties of polyphenols. Many clinical trials and epidemiological studies have also shown that long-term consumption of polyphenol-rich diet protects against chronic metabolic diseases. It is known that polyphenols can modulate the composition of core gut microbiota and interact with the immunometabolism. In the present article, we review the mechanisms of gut microbiota and its metabolites on immunometabolism, summarize recent findings on how the interaction between microbiota and polyphenol modulates host immunometabolism, and discuss future research directions.

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“…Polyphenols may exert some of their effects through the modulation of oral and gut microbiota. The limited evidence currently available from in vitro, pre-clinical and clinical studies is suggesting that some of the effects of polyphenols against colorectal cancer and cardiovascular disease may be related to changes in the relative populations of bacterial subgroups such as Bacteriodes, Lactobacillus, and Bifidobacterium [20,21].…”

Section: Introductionmentioning

confidence: 99%

Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial

Ramos-Romero

Martínez-Maqueda

Hereu

et al. 2020

Foods

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Polyphenols are dietary bioactive compounds able to induce modifications in the gut microbiota profile, although more clinical studies are needed. With this aim, a randomized cross-over clinical trial was conducted, where 49 subjects at cardiometabolic risk (exhibiting at least two metabolic syndrome factors) were supplemented with a daily dose of 8 g of grape pomace (GP) for 6 weeks, with an equivalent control (CTL) period. The levels of total bacteria and Bacteroidetes, Firmicutes, Lactobacilliales, Bacteroides and Prevotella were estimated in fecal DNA by quantitative real-time PCR (qPCR), while fecal short-chain fatty acids (SCFAs) were assessed by gas chromatography. Several cardiometabolic markers were evaluated in blood samples. GP reduced insulin levels only in half of the participants (responders). GP supplementation did not cause significant modifications in the microbiota profile of the whole group, except for a tendency (p = 0.059) towards a decrease in the proportion of Lactobacilliales, while it increased the proportion of Bacteroides in non-responder subjects. The reduction of insulin levels in subjects at cardiometabolic risk upon GP supplementation appears not to be induced by changes in the major subgroups of gut microbiota. Further studies at the species level may help to elucidate the possible role of microbiota in GP-induced insulinemic status.

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Prebiotic potential of polyphenols, its effect on gut microbiota and anthropometric/clinical markers: A systematic review of randomised controlled trials

Cited by 80 publications

References 88 publications

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Bioactive Compounds and Quality of Extra Virgin Olive Oil

Involvement of Gut Microbiota, Microbial Metabolites and Interaction with Polyphenol in Host Immunometabolism

Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial

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