Prebiotics gain prominence but remain poorly defined

Katsnelson, Alla

doi:10.1073/pnas.1618366113

Cited by 14 publications

(6 citation statements)

References 7 publications

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“…"It still fits with the concept that there is some microbial exposure that used to protect us, and that we've lost." For example, Western diets, lacking in plant fiber and other diverse foods that nourish commensal species, appear to disrupt the healthy microbiota in our gut (14).…”

Section: Impoverished Gutmentioning

confidence: 99%

Cleaning up the hygiene hypothesis

Scudellari¹

2017

Proc. Natl. Acad. Sci. U.S.A.

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Section: Impoverished Gutmentioning

confidence: 99%

Cleaning up the hygiene hypothesis

Scudellari¹

2017

Proc. Natl. Acad. Sci. U.S.A.

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“…A prebiotic is currently defined as a substrate that is selectively utilised by host microorganisms conferring a health benefit 132 . Although current definitions of prebiotics have been criticised for not allowing a clear distinction between dietary fibres that are prebiotic and those that are not [133][134][135] , non-digestible carbohydrates (NDCs) can be used to modulate both composition and function of the gut microbiome.…”

Section: Prebioticsmentioning

confidence: 99%

Microbiome-based interventions to modulate gut ecology and the immune system

et al. 2022

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The gut microbiome lies at the intersection between the environment and the host, with the ability to modify host responses to disease-relevant exposures and stimuli. This is evident in how enteric microbes interact with the immune system, e.g., supporting immune maturation in early life, affecting drug efficacy via modulation of immune responses, or influencing development of immune cell populations and their mediators. Many factors modulate gut ecosystem dynamics during daily life and we are just beginning to realise the therapeutic and prophylactic potential of microbiome-based interventions. These approaches vary in application, goal, and mechanisms of action. Some modify the entire community, such as nutritional approaches or faecal microbiota transplantation, while others, such as phage therapy, probiotics, and prebiotics, target specific taxa or strains. In this review, we assessed the experimental evidence for microbiome-based interventions, with a particular focus on their clinical relevance, ecological effects, and modulation of the immune system.

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“…The concept of prebiotics has been proposed for more than 21 years [ 240 ]. Preclinical data have shown that it can recover the intestinal tract damage, metabolism abnormalities, reduce the incidence of colorectal cancer, immune function and glucose intolerance.…”

Section: Treatment and Adjustmentmentioning

confidence: 99%

Implications of Gut Microbiota in Complex Human Diseases

Meng

Vos

et al. 2021

IJMS

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Humans, throughout the life cycle, from birth to death, are accompanied by the presence of gut microbes. Environmental factors, lifestyle, age and other factors can affect the balance of intestinal microbiota and their impact on human health. A large amount of data show that dietary, prebiotics, antibiotics can regulate various diseases through gut microbes. In this review, we focus on the role of gut microbes in the development of metabolic, gastrointestinal, neurological, immune diseases and, cancer. We also discuss the interaction between gut microbes and the host with respect to their beneficial and harmful effects, including their metabolites, microbial enzymes, small molecules and inflammatory molecules. More specifically, we evaluate the potential ability of gut microbes to cure diseases through Fecal Microbial Transplantation (FMT), which is expected to become a new type of clinical strategy for the treatment of various diseases.

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Prebiotics gain prominence but remain poorly defined

Cited by 14 publications

References 7 publications

Cleaning up the hygiene hypothesis

Cleaning up the hygiene hypothesis

Microbiome-based interventions to modulate gut ecology and the immune system

Implications of Gut Microbiota in Complex Human Diseases

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