In this chapter, based on the available geological information, a model for the genesis and evolution of the Uruguayan landscape is proposed. A structural framework of the landscape evolution is provided and the record of such evolution in the most representative geological units is considered. A brief summary of the Uruguayan geology and its location in the regional context is performed, from Precambrian to Cenozoic times.From the analysis of the geological record, it may be observed that the climate was very arid during part of the Jurassic and the Early Cretaceous. Together with the lava flows of the Arapey Formation, the climate became less arid as the Gondwana continents were becoming apart from each other. However, the geological record suggests that semiarid climates were still prevailing. In the Middle Cretaceous, semiarid and wetter climates progressively alternated, until the Early Tertiary, when very wet and warm conditions were established, in coincidence with the "Palaeocene-Eocene Thermal Maximum (PETM)", followed by semiarid climates in the Oligocene, wetter conditions in the Miocene and semiarid again in the Pliocene, with alternating semiarid and humid conditions during the entire Quaternary. D. Panario ( ) • O. Gutiérrez UNCIEP,