2016
DOI: 10.1159/000452957
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Precapillary Pulmonary Hypertension and Sleep-Disordered Breathing: Is There a Link?

Abstract: Among patients with sleep apnea the reported prevalence of precapillary pulmonary hypertension (PH) has varied largely, depending on patient selection, disease definition, and associated conditions, in particular chronic pulmonary disease. However, in the absence of comorbidities, PH seems to be rare in patients with sleep apnea. Conversely, sleep-related breathing disorders have been commonly found in patients with PH and they have been associated with an impaired quality of life. Since sleep-related breathin… Show more

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Cited by 24 publications
(15 citation statements)
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“…There is increasing evidence that pulmonary hypertension is associated with breathing instability. 30 , 31 Reducing hypoxic pulmonary vasoconstriction by the dexamethasone-mediated increase in alveolar ventilation and alveolar P o 2 might have contributed to the reduced AHI level.…”
Section: Discussionmentioning
confidence: 99%
“…There is increasing evidence that pulmonary hypertension is associated with breathing instability. 30 , 31 Reducing hypoxic pulmonary vasoconstriction by the dexamethasone-mediated increase in alveolar ventilation and alveolar P o 2 might have contributed to the reduced AHI level.…”
Section: Discussionmentioning
confidence: 99%
“…PH is a fatal disease known to eventually progress to right ventricular (RV) failure and premature death in many cases [6][7][8][9][10][11][12]. It is still unknown to what extent SDB contributes to impaired oxygenation, sleep disruption, increased daytime sleepiness, and exercise intolerance in patient with PH [1][2][3][4][5][6]13]. Furthermore, the prevalence and clinical determinants of different types of SDB in patients with PH remain unclear.…”
Section: Introductionmentioning
confidence: 99%
“…The CTEPH patients had worse nocturnal hypoxia than the IPAH patients despite the fact that there were no signifi-cant differences in the mean pulmonary artery pressure or pulmonary vascular resistance. Many previous reports have described SDB, especially CSA, in cases of pulmonary hypertension (4,18). Prisco et al reported the correlation between the severity of pulmonary hypertension and comorbid sleep-disordered breathing (19).…”
Section: Discussionmentioning
confidence: 99%