Precautions and Monitoring of Patients Taking Phosphodiesterase Type 5 Inhibitors Who are at Risk of Increased Intraocular Pressure

Baker, Joshua; Fintelmann, Robert E.; Sharifi, Roohollah; Lee, Mary

doi:10.1007/s40266-019-00699-0

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Moreover, we found that VD of RCP is dramatically reduced in the group of patients taking tadalafil. These results on optic disc VD may be correlated with the reported association of non-arteritic anterior ischemic optic neuropathy (NAION) and PDE5is [ 29 , 30 , 31 ]. Campbell et al found an approximately twofold increased risk of acute NAION in men using PDE5is compared to naïve patients [ 6 ].…”

Section: Discussionsupporting

confidence: 75%

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

et al. 2021

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Retinal, choroidal and optic disc vascularity has never been evaluated in patients taking PDE5is long-term. The aim of our study was to evaluate the neurostructural and vascular changes after long-term use of tadalafil, using spectral domain (SD)-optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present clinical trial, 27 patients who have been taking tadalafil 20 mg on alternate days (OAD) for at least 6 months (Group A) were enrolled. The matched group consisted of 27 healthy men (Group B). Both groups of patients underwent SD-OCT to study ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and choroidal thickness and OCTA for the evaluation of superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC) and radial peripapillary capillary (RPC). A reduction in SCP, DCP and RPC vessel density was found in patients using tadalafil long-term. Retinal and optic disc toxicity may be detected using modifications of capillary vessel density. Further studies are needed to investigate the possibility of a causal association.

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Section: Discussionsupporting

confidence: 75%

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

et al. 2021

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“…In at least two reports, ED drug usage was associated with the risk of seroconversion (Ostrow et al, 2009;Prestage et al, 2009), and its use in combination with recreational drugs and sexual behaviors may have even greater detrimental effects, particularly among MSM. As has been suggested in prior studies (Baker et al, 2019;Chu et al, 2003;Garin et al, 2017;Ryan et al, 2018;Swearingen & Klausner, 2005), we may need to provide better public health guidance to persons who use ED drugs, keeping in mind that some persons obtain ED drugs from non-prescriber sources for recreational use. With aging, the use of ED drugs will increase among sexually active men, and intervention strategies may be needed to prevent HIV transmission.…”

Section: Public Health Implicationsmentioning

confidence: 99%

Characteristics and Longitudinal Patterns of Erectile Dysfunction Drug Use Among Men Who Have Sex with Men in the U.S.

Park

Dobs

et al. 2021

Arch Sex Behav

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We investigated the longitudinal relationship between erectile dysfunction (ED) drug use with behavioral factors, including substance use and sexual activities in men who have sex with men from the Multicenter AIDS Cohort Study during 1998–2016 (n = 1636). We used a bivariate random-intercept model to evaluate ED drug use along with other behavioral factors to assess relationships between the two outcomes over time on a population level and also at the individual level. Average ED drug use among men who have sex with men (MSM) with HIV was positively correlated with average use of marijuana (r = .19), poppers (r = .27), and stimulants (r = .25). In this group, testosterone use (r = .32), multiple partners (r = .41), insertive anal intercourse with condom (r = .40), and insertive anal intercourse without condom (r = .43) all showed moderate correlations over time with average ED use (p < .001). Associations among MSM without HIV were similar, with average marijuana use (r = .19) and stimulant use (r = .22) being positively correlated with average ED drug use, and were also correlated with having multiple partners (r = .36), insertive anal intercourse with condom (r = .22), and insertive anal intercourse without condom (r = .18) over time. Positive within-individual associations between ED drug use and multiple partners and insertive anal intercourse with and without condom were observed regardless of HIV serostatus. This study showed that MSM who reported use of ED drugs were also, on average, more likely to use recreational drugs and engage in sexual activities, such as having multiple partners and insertive anal intercourse. Within individuals, average ED drug use was also positively correlated with sexual behaviors.

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Monitor recipients of phosphodiesterase type 5 inhibitors for glaucoma, pending more clinical evidence of risk

Writers¹

2020

Drugs Ther Perspect

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Precautions and Monitoring of Patients Taking Phosphodiesterase Type 5 Inhibitors Who are at Risk of Increased Intraocular Pressure

Cited by 6 publications

References 21 publications

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study

Characteristics and Longitudinal Patterns of Erectile Dysfunction Drug Use Among Men Who Have Sex with Men in the U.S.

Monitor recipients of phosphodiesterase type 5 inhibitors for glaucoma, pending more clinical evidence of risk

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