Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients

Abstract

The role of preceding infection as a risk factor for ischaemic stroke was investigated in a case-control study of 54 consecutive patients under 50 years of age with brain infarction and 54 randomly selected controls from the community matched for sex and age. Information about previous illnesses, smoking, consumption of alcohol, and use of drugs was taken. A blood sample was analysed for standard biochemical variables and serum cholesterol, high density lipoprotein cholesterol, triglyceride, and fasting blood glucose concentrations determined. Titres of antimicrobial antibodies against various bacteria, including Staphylococcus, Streptococcus, Yersinia, and Salmonelia and several viruses were determined. Febrile infection was found in patients during the month before the brain infarction significantly more often than in controls one month before their examination (19 patients v three controls; estimated relative risk 9-0 (95% confidence interval 2-2 to 80.0)). The most common preceding febrile infection was respiratory infection (80%). Infections preceding brain infarction were mostly of bacterial origin based on cultural, serological, and clinical data. In conditional logistic regression analysis for matched pairs the effect of preceding febrile infection remained significant (estimated relative risk 14-5 (95% confidence interval 1*9 to 112-3)) when tested with triglyceride concentration, hypertension, smoking, and preceding intoxication with alcohol.Although causality cannot be inferred from these data and plausible underlying mechanisms remain undetermined, preceding febrile infection may play an important part in the development of brain infarction in young and middle aged patients.

Incident Stroke and Mortality Associated With New-Onset Atrial Fibrillation in Patients Hospitalized With Severe Sepsis

“…Consistent with previous reports of increased stroke risk following infection, [31][32][33][34][35] our study demonstrates that patients with severe sepsis had a six-fold increased risk for in-hospital stroke compared with hospitalized patients without severe sepsis. Importantly, patients with severe sepsis who developed new-onset AF had a greater risk of in-hospital stroke than patients with pre-existing AF and individuals without a history of AF.…”

Impact of the Inflammatory and Ischemic Heart Disease Markers Into the Overall Cardiovascular Mortality in Senile Citizens of a Large City (The Data From Sahr Trial)

“…Можно предпо-ложить, что в более возрастной группе не всегда можно воспроизвести четкую взаимосвязь между ФГ и смерт-ностью, о чем пишут немногочисленные авторы. Дей-ствительно Kannel WB., et al и Syrjanen J., et al пока-зали, что корреляция между уровнем ФГ и развитием осложнений от ССЗ особенно четко прослеживается у пациентов молодого и среднего возраста [35,36]. Кроме того, помимо возраста, можно предположить, что в нашем исследовании препараты, принимаемые (аспирин, статины и др.)…”

Association of variable number of tandem repeat polymorphism in the IL-4 gene with ischemic stroke in the Chinese Uyghur population

“…Previous studies have reported that acute infections, accompanied by acute-phase inflammation reactions and a prothrombotic state, are associated with an increased risk of acute vascular events, such as myocardial infarction and IS (Syrjänen et al, 1988;Lindsberg and Grau, 2003;Zeller et al, 2005). Susceptibility to infection/inflammation and/or risk of atherosclerosis and IS events were shown to be associated with genetic variations in genes and cytokine receptor genes (Worrall et al, 2003;Markus et al, 2006;Steinbrugger et al, 2009).…”