Precipitation characteristics of paclitaxel in solvent systems with different ion exchange resins

Non-chromatographic Method for the Purification of High-Purity Paclitaxel from Taxus chinensis Using Tandem Cavitation Fractional Precipitation

“…Fractional precipitation is a highly effective and simple purification method based on solubility differences [13,29]. To shorten the long precipitation time (~3 days) of conventional fractional precipitation, studies have attempted to improve the precipitation efficiency using surface area increasing materials, but the precipitation still takes a long time, which limits its application for mass production [30,31]. Recently, cavitation-assisted fractional precipitation, which can dramatically decrease the precipitation time by using negative pressure and ultrasound-induced cavitation, has been developed [13,28,32].…”

Non-chromatographic method for the purification of high purity paclitaxel from Taxus chinensis using tandem cavitation fractional precipitation

“…Fractional precipitation is a highly effective and simple purification method based on solubility differences [13,29]. To shorten the long precipitation time (~3 days) of conventional fractional precipitation, studies have attempted to improve the precipitation efficiency using surface area increasing materials, but the precipitation still takes a long time, which limits its application for mass production [30,31]. Recently, cavitation-assisted fractional precipitation, which can dramatically decrease the precipitation time by using negative pressure and ultrasound-induced cavitation, has been developed [13,28,32].…”