With the aim of assessing the degradation of Zr-2.5Nb pressure tubes operating in the Wolsong unit-1 nuclear power plant, characterization tests are being conducted on irradiated Zr-2.5Nb tubes removed after 10-year operation. The examined tube had been exposed to temperatures ranging from 264 to 306 o C and a neutron fluence of 8.9×10 21 n/cm 2 (E>1 MeV) at the maximum. Tensile tests were carried out at temperatures ranging from RT to 300 o C. The density of a-type and c-type dislocations was examined on the irradiated Zr-2.5Nb tube using a transmission electron microscope. Neutron irradiation up to 8.9×10 21 n/cm 2 (E>1 MeV) yielded an increase in a-type dislocation density of the Zr-2.5Nb pressure tube to 7.5×10 14 m −2 , which was highest at the inlet of the tube exposed to the low temperature of 275 o C. In contrast, the c-component dislocation density did not change with irradiation, keeping an initial dislocation density of 0.8×10 14 m −2 over the whole length of the tube. As expected, the neutron irradiation increased mechanical strength by about 17-26% in the transverse direction and by 34-39% in the longitudinal direction compared to that of the unirradiated tube at 300 o C. The change in the mechanical properties with irradiation is discussed in association with the microstructural change as a function of temperature and neutron fluence.